UID:
almahu_9948025959102882
Format:
1 online resource (567 p.)
ISBN:
1-281-03301-4
,
9786611033019
,
0-08-053602-6
Content:
Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models
Note:
Description based upon print version of record.
,
Front Cover; Mechanisms and Models in Rheumatoid Arthritis; Copyright Page; Contents; Introduction; List of Contributors; Section 1: Introduction to Rheumatoid Arthritis; Chapter 1. Clinical Aspects of Rheumatoid Arthritis; Chapter 2. Aetiopathogenesis of Rheumatoid Arthritis; Chapter 3. Mycoplasmas, Superantigens and Autoimmune Arthritis; Chapter 4. Therapy for Rheumatoid Arthritis; Section 2: Pathology of Rheumatoid Arthritis; Chapter 5. Histopathology of the Rheumatoid Joint; Chapter 6. Cellular Mechanisms of Cartilage Destruction; Chapter 7. Immunohistochemistry of Rheumatoid Synovium
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Section 3: Cellular Mechanisms in Rheumatoid ArthritisChapter 8. Fibroblastic Synovial Lining Cells (Synoviocytes); Chapter 9. Cellular Biology of Cartilage Degradation; Chapter 10. Bone Cells and Bone Remodelling in Rheumatoid Arthritis; Chapter 11. Leukocyte Adhesion and Leukocyte Traffic in Rheumatoid Arthritis; Section 4: Humoral Mediators in Rheumatoid Arthritis; Chapter 12. Growth Factors in the Pathogenesis of Rheumatoid Arthritis; Chapter 13. Naturally Occurring Cytokine Inhibitors in Rheumatoid Arthritis
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Chapter 14. Approaches to Novel Anti-arthritic Drugs by Modulation of the Arachidonic Acid CascadeChapter 15. Free Radicals and Rheumatoid Disease; Chapter 16. Neuropeptides and the Synovium; Chapter 17. Proteinases and Connective Tissue Breakdown; Section 5: Animal Models of Rheumatoid Arthritis; Chapter 18. Role of Animal Models in the Study of Rheumatoid Arthritis: an Overview; Chapter 19. Immunogenetics of Animal Models of Rheumatoid Arthritis; Chapter 20. Adjuvant Arthritis: the First Model; Chapter 21. Arthritis Induced by Bacteria and Viruses
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Chapter 22. Bacterial Cell-wall Induced Arthritis: Models of Chronic Recurrent Polyarthritis and Reactivation of Monoarticular ArthritisChapter 23. Collagen-induced Arthritis; Chapter 25. Spontaneous Arthritis Models; Chapter 26. Cytokines in Models of Arthritis; Chapter 27. Transgenic Animals in Rheumatoid Arthritis Research; Chapter 28. The Use of Animals in the Search for Anti-inflammatory Drugs; Color Plate Section
,
English
Additional Edition:
ISBN 0-12-340440-1
Language:
English
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