UID:
almahu_9949697880202882
Umfang:
1 online resource (427 p.)
ISBN:
1-281-03309-X
,
9786611033095
,
0-08-053554-2
Inhalt:
Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of research disciplines. This book brings together current fin
Anmerkung:
Description based upon print version of record.
,
Front Cover; Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms; Copyright Page; Contents; Contributors; Preface; Chapter 1. Liver Regeneration Then and Now; I. Landmarks; II. Normal Adult Rat Liver; III. Liver Regeneration; IV. Hepatocyte Priming; V. Regeneration Signals; VI. Conclusions; References; Chapter 2. Hepatocyte Growth Factor (HGF) and Its Receptor (Met) in Liver Regeneration, Neoplasia, and Disease; I. Introduction; II. Structural and Functional Aspects of HGF and the HGF Receptor; III. HGF Localization; IV. Liver and the Processing of HGF
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V. HGF and the Early Proteolytic Events Following Partial HepatectomyVI. HGF Localization; VII. Summary; References; Chapter 3. Structure and Functions of the HGF Receptor (c-Met); I. Hepatocyte Growth Factor and Scatter Factor; II. HGF Receptor; III. Regulation of c-met Expression; IV. Role of HGF in Tissue Regeneration and Embryogenesis; V. Role of c-met in Carcinogenesis; References; Chapter 4. Expression and Function of Growth-Induced Genes during Liver Regeneration; I. Liver Regeneration: The Important Questions; II. Immediate-Early Gene Expression in Hepatic Cells
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III. Modification of Preexisting Transcription Factors Immediately Following Partial Hepatectomy Turns on Immediate-Early GenesIV. Induction Patterns of 70 Genes Following Partial Hepatectomy Define the Temporal Course of Liver Regeneration; V. Transcription Factors Induced in the Regenerating Liver; VI. Immediate-Early Genes Involved in Signal Transduction; VII. Immediate-Early Genes That Are Secreted Proteins; VIII. Liver-Specific Immediate-Early Genes: Relationship to the Maintenance of Hepatocyte Differentiation and Metabolism
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IX. Immediate-Early Genes in H35 Cells That Are Expressed as Delayed-Early Genes in Regenerating LiverX. Conclusions; References; Chapter 5. Stem Cells and Hepatocarcinogenesis; I. Introduction; II. Cellular Biology of the Hepatic Stem Cell Compartment; III. Neoplastic Development in the Liver; IV. Conclusions; References; Chapter 6. Contributions of Hepadnavirus Research to Our Understanding of Hepatocarcinogenesis; I. General Overview of Hepadnavirus Animal Models and Hepatocarcinogenesis; II. Hepatitis B Virus Envelope Protein (HBsAg) Transgenic Mice
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III. Woodchuck Hepatitis Virus (WHV) Model of HepatocarcinogenesisIV. Hepadnavirus X Gene Encodes an Oncogenic Transcriptional Transactivator; V. Conclusions; References; Chapter 7. Apoptosis and Hepatocarcinogenesis; I. Apoptosis and Other Types of Active Cell Death; II. Active Cell Death in the Liver; III. Biochemical and Molecular Aspects of Apoptosis; IV. Active Cell Death in the Stages of Hepatocarcinogenesis; V. Conclusions; References; Chapter 8. Liver Tumor Promotion and the Suppression of p53-Dependent Cell Cycle Checkpoint Function; I. Introduction
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II. Mechanisms of Cell Cycle Control
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English
Weitere Ausg.:
ISBN 0-12-385355-9
Sprache:
Englisch
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