Kooperativer Bibliotheksverbund

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Format: 1 online resource (711 p.)

Edition: 1st ed.

ISBN: 1-281-03812-1 , 9786611038120 , 0-08-055137-8

Content: In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects.

Note: Description based upon print version of record. , Front Cover; Molecular Photofitting; Copyright Page; Table of Contents; Foreword; Preface; Acknowledgments; Chapter 1: Forensic DNA Analysis: From Modest Beginnings to Molecular Photofitting, Genics, Genetics, Genomics, and the Pertinent Population Genetics Principles; Part I: Introduction: Brief History of DNA in Forensic Sciences; The Statistics of Forensic DNA Analysis; The Nature of Human Genetic Variation; Population Genetics and Population Genomics; The Promise of Molecular Photofitting as a Tool in Forensic Science; Part II: The Basic Principles , Lack of Human Diversity Relative to Other SpeciesChapter 2: Ancestry and Admixture; What Are Ancestry and Admixture?; The Need for Molecular Tests for Ancestry; Ancestry Informative Markers; Biogeographical Ancestry Admixture as a Tool for Forensics and Physical Profiling; Chapter 3: Biogeographical Ancestry Admixture Estimation-Theoretical Considerations; Estimating by Anthropometric Trait Value; Admixture and Gene Flow Estimated from Single Loci; Admixture in Individual Samples; Using the Hanis Method on Population Models k〉2; Parameter Uncertainty , Bayesian Methods for Accommodating Parameter UncertaintySampling Error; Assumptions about Marker Linkage and Intensity of Admixture in Parents; Pritchard's Structure Program; In Defense of a Simple Admixture Model; Practical Considerations for Building an Ancestry Admixture Test; Selecting AIMs from the Genome-How Many Are Needed?; Comparing the Power of Specific Loci for Specific Resolutions; Genomic Coverage of AIMs; More Elaborate Methods of Selecting Markers for Information Content; Shannon Information; Fischerian Information Content; Informativeness for Assignment; Type of Polymorphisms , Interpretation of Ancestry EstimatesObjective Interpretation; Genetic Mapping and Admixture; Appendix (Ancestry Frequency Table); Chapter 4: Biogeographical Ancestry Admixture Estimation-Practicality and Application; The Distribution of Human Genetic Variability and Choice of Population Model; Marker Selection; Sample Collection; Presenting Individual Biogeographical Ancestry (BGAA) Results; Conceptual Issues; Chapter 5: Characterizing Admixture Panels; Parental Sample Plots; Model Choices and Dimensionality; Size of Confidence Contours; Repeatability; Sensitivity , Analysis of Results for GenealogistsAnalysis of Results for Nongenealogists; Blind Challenge of Concordance with Self-Assessed Race; Confidence Interval Warping; Sampled Pedigrees; Simulated Pedigrees; Comparing Different Algorithms with the Same AIM Panel; Analysis Using Subsets of Markers; Resolving Sample Mixtures; Sample Quantity; Nonhuman DNA; Performance with Altered Parental Allele Frequencies; Correlation with Anthropometric Phenotypes; Simulations; Creating Simulated Samples; Source of Error Measured with Simulations; Relationship between Error in Populations and within Individuals , Precision of the 71 AIM Panel from Simulations , English

Additional Edition: ISBN 0-12-088492-5

Language: English