Umfang:
Online-Ressource (XV, 200 p. 98 illus, digital)
ISBN:
9788132210900
Serie:
SpringerLink
Inhalt:
Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and re
Anmerkung:
Includes bibliographical references and index
,
Preface; Acknowledgments; Contents; About the Author; 1 Bacteria and Science of Genetics; 1.1…Bacterial Nucleoid; 1.2…GeneticGenetic NomenclatureGeneticnomenclature; 1.3…Methods of GeneticGenetic AnalysisGeneticanalysis; 1.3.1 Dominance TestDominance test; 1.3.2 ComplementationComplementation Test; 1.3.2.1 Intragenic ComplementationComplementation; 1.3.3 RecombinationRecombination and GeneGene Mapping:; 1.3.4 DeletionDeletion Mapping; 1.4…What is a Bacterial CrossCross?; 1.4.1 Analysis of CrossCross; 1.4.2 Isogenic Lines; 1.5…GeneticGenetic ExchangeGeneticexchange in BacteriaBacteria
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Further Readings2 Gene Mutation: The Basic Mechanism for Generating Genetic Variability; 2.1…What is MutationMutation?; 2.2…Why MutationMutation?; 2.3…Detection of MutationMutation; 2.3.1 Screening; 2.3.2 Selection; 2.4…Characterization of MutationMutation; 2.5…Biochemical Nature of MutationMutation; 2.6…Spontaneous Mutations; 2.6.1 Random, Non-adaptive MutationMutation; 2.6.2 MutationMutation RateMutationrate; 2.6.3 Mechanism of Spontaneous MutationMutation; 2.6.3.1 Errors in DNADNA ReplicationDNAreplication; 2.6.3.2 Deletions; 2.6.3.3 Lesions; 2.6.3.4 Oxidation of Bases
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2.6.3.5 Transposable ElementsTransposable Elements2.7…Induced Mutations; 2.7.1 Physical Mutagens; 2.7.2 Chemical Mutagens; 2.7.3 Base Analogs; 2.7.4 Frameshift Mutagens; 2.8…DNADNA Damage and Repair Pathway; 2.8.1 Deamination; 2.8.1.1 Deamination Repair; 2.8.2 Very Short Patch (VSP) Repair of Deaminated Methylcytosine; 2.8.3 Reactive OxygenOxygen Damage; 2.8.4 AlkylationAlkylation; 2.8.5 UV-IrradiationUV-Irradiation; 2.9…General Repair Mechanisms; 2.9.1 Methyl-Directed Mismatch Repair; 2.9.2 Nucleotide Excision Repair; 2.9.3 SOSSOS Inducible RepairSOSinducible repair
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2.9.4 Post-replication or RecombinationRecombination Repair2.9.5 Inter-Strand Cross-link Repair; 2.10…Site-Directed MutagenesisMutagenesis; 2.10.1 Simple Deletions or Insertions; 2.10.2 Oligonucleotide-Mediated MutagenesisMutagenesis; 2.10.3 In vitro MutagenesisMutagenesis of Double-Stranded/Single-Stranded DNADNA with Chemical Mutagens; 2.10.4 Systematic DeletionDeletion and Insertions; 2.10.4.1 Linker Insertion MutagenesisMutagenesis; 2.10.5 PCR MutagenesisMutagenesis; 2.11…Why are Mutations Important ?; 2.11.1 Identification of GeneGene Function
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2.11.2 Elucidation of the Metabolic Pathways2.11.3 Understanding the Regulatory Pattern of a Metabolic Pathway; 2.11.4 Correlation of an In Vitro Biochemical Activity with an In Vivo Function; 2.11.5 Identification of the Site of Action of an External Agent; 2.11.6 Indication of a Relationship Between Two Systems; 2.11.7 Revealation of Protein--Protein Interaction; 2.11.8 Estimation of the Number of GeneGene Controlling a PhenotypePhenotype and the Functional Differentiation Within a GeneGene; 2.11.9 Basic Source of Variability; 2.12…ReversionReversion and Suppression
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2.12.1 Intragenic Suppressor
Weitere Ausg.:
ISBN 9788132210894
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Srivastava, Sheela Genetics of bacteria New Delhi : Springer, 2013 ISBN 9788132210894
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Bakterien
;
Genetik
DOI:
10.1007/978-81-322-1090-0
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