Umfang:
Online-Ressource
ISBN:
9789048130405
,
9789048130399
Serie:
SpringerLink
Inhalt:
Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.
Anmerkung:
Includes bibliographical references and index
,
Preface; Contents; Contributors; 1 Introduction; References; Part I Bone Marrow-Derived Stem Cells; 2 Hematopoietic Stem and Progenitor Cells in Clinical Use Transplantation and Mobilization; 2.1 Historical Aspects; 2.2 Stem Cell Donors; 2.3 Stem Cell Mobilization and Autologous Transplantation; 2.4 Allogeneic Transplantation; 2.5 Outlook; References; 3 Ex Vivo Expansion of HSPCs; 3.1 The Sources of HSPCs; 3.1.1 Bone Marrow HSPCs; 3.1.2 Peripheral HSPCs; 3.1.3 Umbilical Cord Blood HSPCs; 3.2 The Expansion of HSPCs; 3.2.1 Cytokines; 3.2.2 Ex Vivo Expansion of HSPCs
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3.2.3 Regulation of HSPCs Expansion3.2.4 Free Radical Regulation on HSPCs Expansion; 3.2.5 Megakaryocytic Progenitor Cells Expansion; 3.2.6 Red Cells Expansion; 3.2.7 T-Cell Expansion; 3.2.8 NK Cell Expansion; 3.2.9 DC Expansion; 3.2.10 HSPC Ex Vivo Expansion and Gene Therapy; 3.3 Expansion Bioreactor; 3.4 The Application of Expanded HSPCs; 3.4.1 Transplantation of HSPCs in Animal Model; 3.4.2 Transplantation of HSPCs in Human; 3.5 The Future of HSPCs Expansion; References; 4 Modulation of Hematopoietic Stem/Progenitor Cell Migration; 4.1 Introduction; 4.2 The SDF-1/CXCR4 Axis
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4.2.1 Stromal Cell-Derived Factor-1 (SDF-1)4.2.2 CXCR4; 4.2.3 SDF-1/CXCR4 Signaling; 4.3 Homing of HSPCs to Bone Marrow and Organs; 4.4 Influence of Culture Conditions on the Migration of Human CD34 + /CD133 + Cord Blood HSPCs; 4.5 Influence of Culture Conditions on the Migration of Murine Lin - c-kit + HSPCs; 4.6 Termination of the SDF-1 Induced Migration of HSPCs; 4.7 Conclusion; References; 5 Properties of Mesenchymal Stem Cells to Consider for Cancer Cell Therapy; 5.1 Identifying MSCs; 5.2 Tissue Origin of MSCs; 5.3 Induced Pluripotent Stem Cells and MSCs
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5.4 MSC Homing in Tissue Repair and Oncogenesis5.5 MSCs Tumor Tropism and Pro-metastatic Effects; 5.6 Chemokine Receptors Regulating MSCs Homing; 5.7 Growth Factor Receptors Regulating MSCs Homing; 5.8 Toll-Like Receptors and Death Receptors in MSC Migration; 5.9 Oncogenic Potential of MSCs; 5.10 Immunosuppressive Effects of MSCs; 5.10.1 T Cells; 5.10.2 NK Cells; 5.10.3 DCs; 5.10.4 B Cells; 5.11 Modulation of MSCs Immunosuppression; 5.12 MSCs for Cellular Gene Therapy; 5.13 Retroviral Vectors for MSC Gene Transfer; 5.14 Electroporation for MSC Gene Transfer
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5.15 Ex Vivo Reprogramming of MSCs Without Gene Transfer5.16 Cytokine-Producing MSCs for Cancer Cell Therapy; 5.17 Oncolytic Virus-Infected MSCs; 5.18 Conclusion; References; Part II Embryonic Stem Cells; 6 Alternative Embryonic Stem Cell Sources; 6.1 Introduction; 6.2 Embryonal Carcinoma (EC) Cells; 6.3 Embryonic Stem (ES) Cells; 6.3.1 Hallmarks of ES Cells; 6.3.2 Regulation of Self-Renewal and Pluripotency of ES Cells; 6.3.2.1 Extrinsic Factors; 6.3.2.2 Transcriptional Regulation; 6.3.2.3 Epigenetic Regulation; 6.3.2.4 MicroRNAs; 6.4 Alternative Sources of Pluripotent Stem Cells
,
6.4.1 Derivation of Pluripotent Stem Cells by Reprogramming of a Somatic Nucleus
Weitere Ausg.:
ISBN 9789048130399
Weitere Ausg.:
Buchausg. u.d.T. Stem Cell Biology in Health and Disease Dordrecht : Springer, 2009 ISBN 9789048130399
Weitere Ausg.:
ISBN 9789048130405
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Stammzelle
;
Therapie
DOI:
10.1007/978-90-481-3040-5
URL:
Volltext
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