Format:
Online-Ressource (XX, 583p, digital)
ISBN:
9789400704954
Series Statement:
SpringerLink
Content:
The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
Note:
Includes bibliographical references and index
,
Preface; About the Author; Contents; Introduction; Measuring Health and Disease; Is There a Better Definition of Health?; Determinants of Health; Maintaining Health; Observations of Daily Living; Social Activity; Hygiene; Stress Management; Health Care; Workplace Wellness Programs; Public Health; Role of Science in Health; Applied Health Sciences; Health and Disease as Two Sides of the Same Coin; Low-Grade Systemic Inflammation Occurs in Many Diseases; Inflammation; Introduction; Phases of Inflammatory Response; Components of Acute Inflammation; Mediators of Inflammation
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Effects of Food ContentLocation of Serotonergic Neurons; 5-HT Receptors; Serotonylation; Biosynthesis of Serotonin; Drugs Targeting the 5-HT System; Serotonin Modulates Inflammation and Immune Response; Acetylcholine; Melanocortin; Leptin; Neuropeptide Y; Ghrelin; Gut Peptides; Cholecystokinin; Essential Fatty Acids and Their Products; Cyclo-oxygenase (COX), Lipoxygenase (LO) Pathways and Generation of Lipoxins, Resolvins, Protectins and Maresins; Aspirin-triggered 15 Epimer LXs (ATLs) and Resolvinsand Formation of Protectins and Maresins; Platelet Activating Factor (PAF)
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Cytokines in InflammationChemokines in Inflammation; Nitric Oxide (NO); NO is an Endogenous Anti-infective Molecule; NO and Cellular Senescence; NO and Brain-derived Neurotrophic Factor (BDNF); Leukocyte Lysosomal Enzymes; Reactive Oxygen Species (ROS); Neuropeptides in Inflammation; Diagnosis of Low-grade Systemic Inflammation; Hs-CRP; Cytokines and Chemokines; Conventional Markers of Inflammation; Role of Pro-inflammatory Markers in the Pathophysiologyof the Low-grade Systemic Inflammatory Conditions; Essential Fatty Acids---Biochemistry, Physiology and Clinical Significance; Introduction
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Metabolism of EFAsDietary Sources of EFAs; The Activities of '1046 and '1045 Desaturases Are Low in Humans; Modulators of EFAs/PUFAs Metabolism; Actions of EFAs/PUFAs and Their Metabolites; Cell Membrane Organization; Introduction; Fluid Mosaic Model of the Membrane; The Phospholipid (PL) Bilayer---Its Structure, Propertiesand Functions; Low-grade Systemic Inflammation is Present in Common Diseases/Disorders; Introduction; Low-grade Systemic Inflammation is Presentin Chronic Diseases; Obesity; Definition of Obesity; Incidence and Prevalence of Obesity; Obesity May Be Familial
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Fast Food Industry and ObesityObesity Is Harmful; Genetic and Non-genetic Factors Contributing to Obesity; Gene Expression Profile in Obesity; All Adipose Cells are Not the Same; Biochemical and Functional Differences Between Adipose Cells of Different Regions; Intramyocellular Lipid (IMCL) Droplets and Perilipins; Perilipins and Inflammation; Low Grade Systemic Inflammation Occurs in Obesity; Weight Loss Ameliorates Inflammation; Adipose Tissue Macrophages (ATMs) and Inflammation; Macrophage Differentiation Is Dependent on FattyAcid Synthesis; Fatty Acid Metabolism Enhances T Cell Memory
,
What Causes Abdominal Obesity---How and Why?
Additional Edition:
ISBN 9789400704947
Additional Edition:
Buchausg. u.d.T. Das, Undurti N. Molecular basis of health and disease Dordrecht : Springer, 2011 ISBN 9789400704947
Language:
English
Subjects:
Medicine
Keywords:
Molekularpathologie
DOI:
10.1007/978-94-007-0495-4
URL:
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