Format:
Online-Ressource (XXV, 290p. 53 illus., 40 illus. in color, digital)
ISBN:
9789400720190
Series Statement:
Tumors of the Central Nervous System 5
Content:
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; respons
Note:
Description based upon print version of record
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Preface; Contents; Contents of Volume 1; Contents of Volume 2; Contents of Volume 3; Contents of Volume 4; Contributors; Part I Astrocytomas: Diagnosis and Biomarkers; 1 Methylation in Malignant Astrocytomas; Understanding the Word Epigenetics; DNA Methylation; Relevance of DNA Methylation in Normal Cells; Epigenetics, Environment, Diet and Aging; DNA Methylation in Human Disease and Cancer; Methods to Detect Methylation; DNA Methylation in Astrocytic Tumors: Genes Frequently Methylated, Relevance for Diagnosis and Prognosis; Relevance of Methylation in the Clinic; Epigenetic Therapy
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Future DirectionsReferences; 2 Deciphering the Function of Doppel Protein in Astrocytomas; Introduction; Historical Background of Doppel Discovery; Doppel Gene Expression Analysis in Astrocytomas: A Novel Potential Tumor Marker; Doppel Protein in Astrocytomas; Biochemical Features and Cellular Localization; Functional Pathways and Interaction Analysis; Conclusion; References; 3 Astrocytic Tumors: Role of Antiapoptotic Proteins; Introduction; Death Ligands, Receptors and Messengers; The p53; Regulation of p53 Activity; P53 and Cell Cycle Progression; P53 and p16/INKa4; P53 and PTEN
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The Bcl-2 Family of ProteinsInhibitor of Apoptosis Proteins; Activation of IAPs in Gliomas; Survivin and Cell Cycle Progression; References; 4 Deregulation of the Wnt/ß -Catenin/Tcf Signaling Pathway in Astrocytomas; Introduction; Molecular Pathogenesis of Glioblastomas; Wnt Signaling Pathway; Cellular Origin-Neural Stem Cells-Wnt Signaling; Activation of Wnt/ß-Catenin/Tcf Signaling Pathway Components in Astrocytomas; Wnt Signaling Antagonists; Wnt Ligands and Frizzled Receptors; Dishevelled and FRAT-1; Axin-APC-GSK3ß; ß-Catenin; Lef-1 and Tcf-4; References
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5 Subependymal Giant Cell Astrocytoma: Role of mTOR Pathway and Its InhibitorsIntroduction; mTOR Pathway in Tuberous Sclerosis Complex; Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis Complex; mTOR Pathway in Subependymal Giant Cell Astrocytoma; Genes Regulating mTOR Activity in Subependymal Giant Cell Astrocytoma; mTOR Inhibitors; mTOR Inhibitors in Tuberous Sclerosis: Lessons from Preclinical Studies; Targeting mTOR in Subependymal Giant Cell Astrocytoma; Conclusions; References; 6 Role of Progesterone Receptor Isoforms in Human Astrocytomas Growth; Introduction; Astrocytomas
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Genomic Mechanism of Action of Progesterone (P)Transcriptional Activity of PR Isoforms; Regulation of PR Isoforms Expression; Role of P in Astrocytomas Proliferation; PR Isoforms Regulation and Function in Astrocytomas; Conclusion and Perspectives; References; 7 Astrocytic Tumors: Role of Carbonic Anhydrase IX; Introduction; Carbonic Anhydrase IX; Expression of Carbonic Anhydrase IX in Normal Tissue; Expression of Carbonic Anhydrase IX in Neoplastic Tissue; Role of Carbonic Anhydrase IX in Carcinogenesis; Immunohistochemical and Analytical Methods
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Evaluation of Carbonic Anhydrase IX in Astrocytic Tumors
Additional Edition:
ISBN 9789400720183
Additional Edition:
Buchausg. u.d.T. ISBN 978-94-007-2018-3
Language:
English
DOI:
10.1007/978-94-007-2019-0
URL:
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