Kooperativer Bibliotheksverbund

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Format: 1 online resource (332 pages)

Edition: 1st ed.

ISBN: 9783031622410

Series Statement: Philosophy and Medicine Series ; v.151

Note: Intro -- Acknowledgement -- Contents -- About the Editors -- About the Authors -- Chapter 1: Introduction -- Chapter 2: Prologue: A Pragmatist Approach to Conceptualization of Health and Disease -- 2.1 Introduction -- 2.2 Background Assumptions and Theoretical Starting Points -- 2.3 Connections with Classical Pragmatism -- 2.4 Problematic Situations Related to Health and Disease Concepts -- 2.4.1 Patients with Symptoms but No Pathology Are Not Understood as Diseased -- 2.4.2 Patients with Pathology or `Biomarkers ́but No Symptoms Are Understood as Diseased -- 2.4.3 Preventive Medicine Aimed at Preventing Pathology or Pathophysiology, as Opposed to Symptoms -- 2.4.4 Overdiagnosis -- 2.4.5 The False Presumption that Patients with the Same Disease Are Homogeneous -- 2.4.6 Problems with the Notion of Health -- 2.4.7 Institutional Designation of the Sick Role -- 2.5 Final Remarks -- References -- Chapter 3: Nature and Culture in Health and Disease: Historical Strategies in Medical Diagnostics for Navigating Between Criti... -- 3.1 Introduction: Diagnostic Essentialism and Nominalism -- 3.2 Diagnosis and Diagnostics Since the Nineteenth Century -- 3.3 Theories of Diagnosis in the 1920s: Crookshank, Koch and Vaihingerś `As-If ́-- 3.4 Conclusion -- References -- Chapter 4: Epistemic Inclusion and the Silence of the Patients -- 4.1 Introduction -- 4.2 The Silence of the Patients -- 4.3 From Continuity to Discontinuity -- 4.4 Epistemic Inclusion -- References -- Chapter 5: The Variety of Historiographical Medical Relativism -- 5.1 Introduction -- 5.2 Cunningham on Incommensurability and Retrospective Diagnosis -- 5.3 Jewsonś Medical Cosmologies and the Modes of Production -- 5.4 Mol on Enactment and Ontological Politics -- 5.5 The Spectrum of Relativism -- 5.6 Cunninghamś Relativism of Distance. , 5.7 Is Cunningham Is Committed to Equal-Validity Relativism? -- 5.8 Jewsonś Locality-Relativism -- 5.9 Molś Ontological Relativism: Between Equal Validity and Distance -- 5.10 Summary and Conclusions -- References -- Chapter 6: Cultivate Your Own Garden-Some Reflections on Martin Kuschś Overview of Relativism in Medical History -- References -- Chapter 7: Is There an Epistemic Role for History in Medicine? Thinking About Thyroid Cancer -- 7.1 Introduction -- 7.2 Cancer and Malignancy in the Nineteenth Century -- 7.3 Bringing Order to Chaos: 1900-1950 -- 7.4 Differentiated and Undifferentiated Tumours -- 7.5 Papillary Carcinomas Comprised Mostly of Follicles -- 7.6 Papillary Carcinoma with no Papillary Structures at All -- 7.7 Lumps that Needed Splitting -- 7.8 Conclusion -- References -- Chapter 8: A Plea for More History -- 8.1 Is it Important? -- 8.2 Is it Convincing? -- 8.3 How to Make it Even More Historical? -- References -- Chapter 9: Scope Validity in Medicine -- 9.1 Introduction -- 9.2 Validity, Scope, and Scope Validity -- 9.2.1 Validity Concepts and the Guiding Ideal of a Construct -- 9.2.2 The Logic of Validation in Animal Models of Human Diseases -- 9.2.3 Scope Validity -- 9.3 Towards a Relational Epistemology -- 9.3.1 A Particularistic Perspective on Disease -- 9.3.2 Scoping Methods -- 9.4 Conclusion -- References -- Chapter 10: Scope Validity in Medicine: An Asset to the Epidemiologistś Armoury -- References -- Chapter 11: The Biomarkerization of Alzheimerś Disease: From (Early) Diagnosis to Anticipation? -- 11.1 Introduction -- 11.2 Biomarkers for Alzheimerś Disease: Food for Thought -- 11.2.1 NIA-AA 2011 -- 11.2.2 NIA-AA 2018 -- 11.2.3 Draft NIA-AA 2023 -- 11.3 Biomarkers and Disease -- 11.4 AD Biomarkers: Promising Homogeneity and Certainty, Producing Heterogeneity and Probabilities. , 11.5 Implications for AD, With or Without Symptoms -- 11.6 Towards Anticipatory Healthcare -- 11.7 In Conclusion -- References -- Chapter 12: Biomarking Life -- 12.1 Do Biomarkers Promote a Shift from Ontological Concepts to Physiological Concepts? -- 12.2 Are Biomarkers Responsible for the Shift to Anticipation? -- 12.3 Do Biomarkers Decouple Disease from Suffering and Put the Person at the Center? -- 12.4 From Marking (What Is) Bad to Defining What Is Good -- 12.5 Conclusion -- References -- Chapter 13: Risk and Disease: Two Alternative Ways of Modelling Health Phenomena -- 13.1 Introduction -- 13.2 Explaining the Blurring of the Disease-Risk Distinction -- 13.2.1 The Plasticity of the Concepts of Risk and Risk Factor -- 13.2.2 About the Distinction Between Cause(s) of Disease and Disease -- 13.2.3 Probabilistic Modelling of Chronic Diseases -- 13.3 Limits of the Functionalist Conceptual Analysis of Disease for the Risk-Disease Distinction -- 13.3.1 The Functionalist Criterion for the Risk-Disease Distinction -- 13.3.2 Risk Level Is Used to Determine the Threshold for Disease -- 13.4 Risk Beyond the Normal-Pathological Dichotomy: An Alternative Gradualist Approach of Health -- 13.4.1 The Epidemiological Risk Approach as an Alternative Way of Modelling Health Phenomena -- 13.4.2 Neither Normal Nor Pathological -- 13.4.3 Advantages of the Risk Approach and a Gradualist Concept of Health -- 13.4.4 Challenges for the Risk Approach and a Gradualist Concept of Health -- 13.5 Conclusion -- References -- Chapter 14: Fundamental Concepts in Medicine: Why Risk and Disease Are Likely to Stay on Board -- References -- Chapter 15: A Pragmatic Approach to Understanding the Disease Status of Addiction -- 15.1 Introduction -- 15.2 The Vague Cluster Account -- 15.2.1 Vagueness -- 15.2.2 Cluster Concept Structure -- 15.2.3 Disease as a Vague Cluster Concept. , 15.3 Addiction as a Borderline Disease -- 15.3.1 Dysfunction -- 15.3.2 Harm -- 15.3.3 Explanation in Biological/Psychological Terms -- 15.3.4 Lack of Direct Conscious Control -- 15.3.5 Conclusion on the disease status of addiction -- 15.4 Pragmatic Considerations in Specifying the Disease Status of Addiction -- 15.4.1 Pragmatic Reasons for Considering Addiction a Disease -- 15.4.2 Reasons Against Taking Addiction to Be a Disease -- 15.5 How Should We Precisify `Disease ́in the Case of Addiction? -- 15.6 Conclusion -- References -- Chapter 16: Addiction and Its Ambiguities: Some Comments from History -- 16.1 Contested Nature of Disease Status -- 16.1.1 The Addiction-Or Substance Use Disorder-Spectrum -- 16.2 Harmfulness of Drugs and Drug Policies -- References -- Chapter 17: Pragmatism in the Fray: Constructing Futures for `Medically Unexplained Symptoms ́-- 17.1 Introduction -- 17.2 A Change of Scene -- 17.3 Turning the Tables on `Somatisation ́-- 17.4 How to Take Symptoms Seriously? -- 17.4.1 `Forget (Biomedical) Explanation! ́-- 17.4.2 `Patients Need (Good) Explanations! ́-- 17.5 The Symptoms Clinic: Explanations as a Wager on an Unfinished Present -- 17.6 Conclusion: Choose Your Pragmatism Carefully -- References -- Chapter 18: The Bodily Deficit in Contemporary Healthcare -- References -- Chapter 19: Conceptual Engineering Health: A Historical-Philosophical Analysis of the Concept of Positive Health -- 19.1 Introduction -- 19.2 A Brief History of the Concept of Positive Health -- 19.2.1 Prelude -- 19.2.2 A Conference and a Position Paper -- 19.2.3 Developing the `New, Dynamic Concept ́into Positive Health -- 19.2.4 Uptake and Implementation -- 19.2.5 Critique -- 19.3 Conceptual Engineering -- 19.3.1 A New Meta-semantical Theory and Philosophical Methodology -- 19.3.2 The Target of Conceptual Engineering. , 19.3.3 Conceptual Engineering in and for Medicine -- 19.4 Methods for Concept Evaluation -- 19.4.1 A Functional Approach -- 19.4.2 Carnapian Explication -- 19.4.3 Ameliorative Analysis -- 19.5 Assessing the Adequacy of Positive Health -- 19.5.1 Method of Choice -- 19.5.2 Through the Lens of Pragmatic Carnapian Explication -- Clarifying the Explicandum and Identifying the Task -- Assessing the Adequacy of the Proposed Explicatum -- 19.5.3 Through the Lens of Ameliorative Analysis -- Critical Analysis -- Assessing the Adequacy of the Ameliorative Concept -- 19.6 Conclusion -- References -- Chapter 20: On the Social and Material Lives of Health Concepts in the Wild -- References -- Chapter 21: Healthism, Elite Capture, and the Pitfalls of an Expansive Concept of Health -- 21.1 Introduction -- 21.2 Healthism and the Moral and Aesthetic Meanings of Health -- 21.3 The Tyranny of the Community -- 21.4 Healthy Eating -- 21.5 Healthy Sexuality -- 21.6 Healthy Gender Identity -- 21.7 Elite Capture of the Concept of Health -- References -- Chapter 22: Pragmatism, Pluralism, Vigilance and Tools for Reflection: A Reply to Quill Kukla -- 22.1 Introduction -- 22.2 Health as a Multifaceted Term and Its Relation to Disease and Well-Being -- 22.3 Health as a Value-Laden Term and the Need for Ongoing Reflection -- 22.4 Conclusion -- References -- Chapter 23: Epilogue: Towards a Toolbox for a Pragmatist Approach to Conceptualization of Health and Disease -- 23.1 Introduction -- 23.2 Insights into Some Problematic Situations -- 23.3 Further Themes and Issues -- 23.3.1 Disease and Diseases -- 23.3.2 Context -- 23.3.3 Concepts, Conceptions and Conceptualizations -- 23.3.4 Functions and Functioning of Concepts -- 23.3.5 Continuity and Change -- 23.4 Towards a Toolbox -- 23.4.1 A Toolbox of Disease Concepts -- 23.4.2 A Pragmatist Working Method -- 23.4.3 Concluding Remarks. , References.

Additional Edition: Print version: Schermer, Maartje A Pragmatic Approach to Conceptualization of Health and Disease Cham : Springer International Publishing AG,c2024 ISBN 9783031622403

Language: English

Keywords: Electronic books.

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Format: 1 online resource (vii, 392 pages) : , digital, PDF file(s).

ISBN: 9780511483011 (ebook)

Content: When considering the question of what makes us human, the ancient Greeks provided numerous suggestions. This book argues that the defining criterion in the Hellenic world, however, was the most obvious one: speech. It explores how it was the capacity for authoritative speech which was held to separate humans from other animals, gods from humans, men from women, Greeks from non-Greeks, citizens from slaves, and the mundane from the heroic. John Heath illustrates how Homer's epics trace the development of immature young men into adults managing speech in entirely human ways and how in Aeschylus' Oresteia only human speech can disentangle man, beast, and god. Plato's Dialogues are shown to reveal the consequences of Socratically imposed silence. With its examination of the Greek focus on speech, animalization, and status, this book offers new readings of key texts and provides significant insights into the Greek approach to understanding our world.

Note: Title from publisher's bibliographic system (viewed on 05 Oct 2015). , I: Speech, animals, and human status in Homer -- Bellowing like a bull: humans and other animals in Homer -- Controlling language: Telemachus learns to speak -- Talking through the heroic code: Achilles learning to tell tales -- II: Listening for the other in classical Greece -- Making a difference: the silence of otherness -- III: Speech, animals, and human status in classical Athens -- Disentangling the beast: humans and other animals in the Oresteia -- Socratic silence: the shame of the Athenians.

Additional Edition: Print version: ISBN 9780521832649

Language: English

Subjects: Ancient Studies

URL: https://doi.org/10.1017/CBO9780511483011

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Format: 1 online resource (180 pages)

Edition: 1st ed.

ISBN: 9783662607565

Series Statement: Beiträge Zum Ausländischen öffentlichen Recht und Völkerrecht Series ; v.290

Note: Studies in Global Animal Law -- Acknowledgments -- Contents -- Chapter 1: Introduction -- 1 Global Animal Law in a Nutshell -- 2 A Globalised Problem Requires a Global Solution -- 3 Global Animal Law as a Response to Outsourcing -- 4 Global Animal Law as an Analytical Lens -- 5 The Contributions to this Volume -- References -- Part I: Historical Foundations -- Chapter 2: Rights of and Over Animals in the ius naturae et gentium (Sixteenth and Seventeenth Centuries) -- References -- Chapter 3: On Women and Beasts: Human-Animal Relationships in Sixteenth-Century Thought -- References -- Chapter 4: Animal Colonialism: The Case of Milk -- 1 Introduction -- 2 Animal Colonialism -- 3 Milk Colonialism -- 4 Breastfeeding Colonialism -- 5 Conclusion: Toward a Trans-Species Right to Breastfeed -- References -- Part II: Animals as Commodity -- Chapter 5: Trading in Sacrifice -- 1 Introduction -- 2 The Live Export Trade -- 3 Religious Motivations for the Importation of Live Animals -- 4 The Legal Regime Governing Live Exports -- References -- Chapter 6: Cross-Border Forms of Animal Use by Indigenous Peoples -- 1 Introduction -- 2 Traditional Livelihoods of a Transnational Indigenous People -- 3 Involving Indigenous Peoples in Decision-Making Processes and Protecting Their Rights in International Agreements -- 4 Animals, Welfare, Animal Welfare and Indigenous Culture -- 5 Concluding Remarks -- References -- Chapter 7: Chinaś Legal Response to Trafficking in Wild Animals: The Relationship between International Treaties and Chinese ... -- 1 Introduction -- 2 Chinaś Law Enforcement and Judicial Measures Against the Trafficking of Wild Animals and Their Products -- 2.1 Law Enforcement Measures -- 2.2 Judicial Measures -- 3 New Chinese Legislation on the Elimination of Trafficking of Wild Animals and Their Products. , 3.1 Interpretation of Crimes Against Wild Animals by the Standing Committee of the National Peopleś Congress -- 3.2 The Wild Animal Protection Law and Its New Provisions -- 3.3 Ban on Ivory and Its Products in Recent Years -- 4 Suggested Improvements to Chinaś Legal Response to Trafficking -- 5 Conclusion -- References -- Chapter 8: Corruption Gone Wild: Transnational Criminal Law and the International Trade in Endangered Species -- 1 Introduction -- 2 Prohibiting Corruption and Wildlife Trafficking Through International Law -- 3 Linking International Norms Against Corruption and Wildlife Trafficking -- 3.1 Research Publications -- 3.2 Soft Law Statements -- 3.3 Security Council Resolutions -- 4 Contesting the Connection Between the Anti-corruption and Anti-wildlife Trafficking Agendas -- 4.1 Effectiveness -- 4.2 Human Rights -- 4.3 Politics -- 5 Conclusion -- References -- Part III: New Legal Concepts -- Chapter 9: Biodiversity, Species Protection, and Animal Welfare Under International Law -- 1 Introduction -- 2 The Scope of Animal Welfare and International Biodiversity Law: Wildlife as an Overlapping Theme -- 3 Animal Welfare: An Absent Topic in General International Biodiversity Law -- 4 Animal Welfare: A Condition for the Sustainable Use and Conservation of Endangered Species -- 5 The Relevance of Complementary International Rules to Ensure Both Wildlife Welfare and Conservation -- References -- Chapter 10: Toward International Animal Rights -- 1 Introduction: The Spectre of Dehumanisation -- 2 The Trend Towards Animal Welfare and Rights in Domestic Laws -- 3 The Need for International Animal Rights -- 4 International Animal Personhood -- 5 Animal Rights and Human Rights: Foundations -- 6 Animal Rights and Human Rights: Universality -- 7 Conclusions -- References. , Chapter 11: (Certified) Humane Violence? Animal Production, the Ambivalence of Humanizing the Inhumane, and What International... -- 1 Introduction: The Industrialization and Humanization of Animal Production -- 2 Humane Labelling and Humane-Washing -- 3 The Inherent Contradiction and Limits of Humanizing Animal Production -- 4 Animal Welfare Law and International Humanitarian Law: A Brief Comparison -- 5 Outlook: From a Jus In Bello Towards a Jus Contra Bellum for Animals -- References -- Part IV: New Protective Legal Strategies -- Chapter 12: Trophy Hunting, the Race to the Bottom, and the Law of Jurisdiction -- 1 Introduction -- 2 Regulating Trophy Hunting in an Era of Globalization: A Lost Cause? -- 3 Are Treaties the Solution? -- 4 The Promises of Extraterritorial Jurisdiction -- 5 Extraterritorial Jurisdiction: Mapping the Options -- 5.1 Lex Lata Options for Regulating Trophy Hunting -- 5.2 Lex Ferenda Options for Regulating Trophy Hunting -- 6 Trophy Hunting Is Only the Tip of the Iceberg -- 7 Concluding Remarks -- References -- Chapter 13: Protection of Animals Through Human Rights: The Case-Law of the European Court of Human Rights -- 1 Introduction -- 2 The Hunting Cases -- 2.1 Hunting Under Article 1 of Protocol 1 -- 2.2 Hunting Under Articles 10 and 11 -- 3 Animal Welfare and Freedom of Speech -- 4 Obstacles and Opportunities -- 5 Final Thoughts -- References -- Chapter 14: Challenges Regarding the Protection of Animals During Warfare -- 1 Introduction -- 2 The Silence of IHL -- 3 The Distinction Between IACs and NIACs -- 4 The Conduct of Hostilities -- 5 The Protection of Individuals -- References.

Additional Edition: Print version: Peters, Anne Studies in Global Animal Law Berlin, Heidelberg : Springer Berlin / Heidelberg,c2020 ISBN 9783662607558

Language: English

Keywords: Electronic books.

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Format: 1 online resource (X, 200 p. 36 illus., 2 illus. in color.)

Edition: 1st ed. 2011.

ISBN: 1-61779-083-4

Series Statement: Methods in Molecular Biology, 732

Content: Since the discovery of microRNAs, developmental biologists have striven to understand the role of miRNAs in development and disease. MicroRNAs in Development: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Divided into three convenient sections, this detailed volume covers various techniques to detect and profile miRNA expression, followed by protocols to manipulate the activity of miRNAs in various organisms, and it concludes with a section that outlines different methods to identify and validate miRNA targets in animals and plants. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, MicroRNAs in Development: Methods and Protocols serves as a practical guide for scientists of all backgrounds and conveys the appropriate sense of fascination associated with this vital field of research.

Note: Bibliographic Level Mode of Issuance: Monograph , In situ Detection of microRNAs in Animals -- Detection of microRNAs in Plants by In situ Hybridization -- Detecting Animal and Plant microRNAs by Northern Blotting -- Profiling microRNAs by Real-time PCR -- Detection of Small RNAs and microRNAs using Deep Sequencing Technology -- Detection of microRNAs in Prostate Cancer Cells by microRNA Array -- microRNA Knock Down by Cholesterol Conjugated Antisense Oligos in Mouse Organ Culture -- Protocols for Use of Homologous Recombination Gene-targeting to Produce microRNA Mutants in Drosophila -- Engineering Elements for Gene Silencing: The Artificial microRNAs Technology -- Mimicry Technology: Suppressing Small RNA Activity in Plants -- Experimental Validation of MicroRNA Targets using a Luciferase Reporter System -- Experimental Identification of microRNA Targets by Immunoprecipitation of Argonaute Protein Complexes -- Comprehensive Identification of miRNA Target Sites in Live Animals -- Target Validation of Plant microRNAs.- A High-throughput Sequencing-based Methodology to Identify All Uncapped and Cleaved RNA Molecules in Eukaryotic Genomes. , English

Additional Edition: ISBN 1-61779-082-6

Language: English

DOI: 10.1007/978-1-61779-083-6

UID:

Format: 204 Seiten

ISBN: 9783608948844 , 3608948848

Language: German

URL: http://deposit.d-nb.de/cgi-bin/dokserv?id=5029219&prov=M&dok_var=1&dok_ext=htm

Author information: Freundl, Hans

Author information: Gray, John

UID:

Format: 1 online resource (317 pages)

Edition: First edition.

ISBN: 0-323-97228-4

Content: CRISPR-Cas System in Translational Biotechnology discusses applied and translational aspects of the CRISPR-Cas technology. The book bridges the gap between theoretical knowledge and practical solutions surrounding this emerging and impactful technology in several academic and industrial fields. It is split in five sections: CRISP-Cas fundamentals and advancements; CRISP-Cas in medical biotechnology; CRISP-Cas in environmental biotechnology; CRISP-Cas in food biotechnology; and biosafety, patents and commercialization of CRISP-Cas technology. Written by experts from diverse backgrounds, the content covers the subject and its impact in multiple fields.

Note: Front Cover -- CRISPR-Cas System in Translational Biotechnology -- Copyright Page -- Contents -- List of contributors -- 1 CRISPR-Cas fundamentals and advances -- 1 CRISPR-Cas9: chronology and evolution -- 1.1 Introduction -- 1.2 Discovery of CRISPR-Cas system -- 1.3 Mechanism of CRISPR-Cas system -- 1.4 Classification of CRISPR-Cas system -- 1.4.1 Class I CRISPR-Cas system -- 1.4.1.1 Type I -- 1.4.1.2 Type III -- 1.4.1.3 Type IV -- 1.4.2 Class II CRISPR-Cas system -- 1.4.2.1 Type II system -- 1.4.2.2 Type V system -- 1.4.2.3 Type VI system -- 1.5 Limitations of CRISPR technology -- 1.5.1 CRISPR-Cas9 off-target effects -- 1.5.2 DNA damage and apoptosis -- 1.5.3 Immunotoxicity -- 1.5.4 Delivery of CRISPR system to hosts -- 1.6 Applications of CRISPR technology -- 1.6.1 Role of CRISPR in gene regulation -- 1.6.2 In metabolic engineering -- 1.6.3 Role of CRISPR in COVID-19 -- 1.6.4 CRISPR for animal model preparation -- 1.7 Conclusions and future perspectives -- References -- 2 CRISPR: the Janus god of modern science -- 2.1 Introduction -- 2.2 Timeline of developments in CRISPR-Cas system -- 2.3 Applications of CRISPR-Cas gene-editing system in human diseases -- 2.3.1 In the treatment of genetic disorders -- 2.3.2 In the treatment of various types of cancer -- 2.3.3 In the treatment of acquired immunodeficiency syndrome -- 2.3.4 In the treatment of neurodegenerative disorders -- 2.3.5 In Coronavirus disease 2019 -- 2.4 Applications of CRISPR system in agriculture for crop improvement -- 2.4.1 Increasing productivity -- 2.4.2 Quality improvement -- 2.4.3 Tolerance to biotic and abiotic stress -- 2.4.4 Herbicide resistance -- 2.4.5 Expediting hybrid breeding -- 2.5 Applications of CRISPR-Cas9 system in environmental science -- 2.5.1 Bioplastic -- 2.5.2 Biofuel -- 2.5.3 Biosensors -- 2.5.4 Bioremediation. , 2.6 Limitations of CRISPR-Cas9 gene-editing system in medicinal, agricultural, and environmental sectors -- 2.6.1 Limitations of CRISPR in the medicinal field -- 2.6.1.1 Mutations -- 2.6.1.2 Immunotoxicity -- 2.6.2 Limitations of CRISPR in agricultural crops -- 2.6.3 Limitations of CRISPR on the environment -- 2.6.4 Implications for Cas and mitigating strategies -- 2.7 Conclusions -- References -- 3 Commercialization of CRISPR-Cas technology: issues and impact -- 3.1 Introduction -- 3.2 CRISPR-Cas IPR dispute: who stands where? -- 3.3 Worldwide patent landscape of CRISPR -- 3.4 A commercial conundrum -- 3.5 Ethical concerns -- 3.6 Challenges in commercialization of CRISPR-Cas -- 3.6.1 Agriculture -- 3.6.2 Medicine -- 3.7 Conclusions -- References -- 2 CRISPR-Cas in medical biotechnology -- 4 CRISPR-Cas-led advancements in translational biotechnology -- 4.1 Introduction -- 4.2 Genome editing tools before CRISPR -- 4.2.1 Zinc finger nucleases -- 4.2.2 Transcription activator-like effector nucleases -- 4.2.3 Adeno-associated viruses -- 4.3 CRISPR technology -- 4.3.1 Components of CRISPR -- 4.3.2 Cas enzymes -- 4.3.2.1 Cas9 -- 4.3.2.2 Cas12a -- 4.3.2.3 Cas13 -- 4.3.3 How does CRISPR work? -- 4.3.3.1 Creation of double-stranded breaks -- 4.3.3.2 Repair of CRISPR-induced double-stranded breaks -- 4.3.3.2.1 Nonhomologous End Joining -- 4.3.3.2.2 Homologous directed repair -- 4.3.4 Channelized workflow of CRISPR -- 4.3.5 Delivery methods of CRISPR components in the cell -- 4.3.5.1 Electroporation -- 4.3.5.2 Lipofection (transfection) -- 4.3.5.3 Microinjection -- 4.4 Knock-outs and knock-ins using CRISPR system -- 4.4.1 Disrupting a gene in the cell line via CRISPR system: knock-out -- 4.4.2 Rectification of gene mutation or designing a fusion protein in cell line: knock-in -- 4.4.3 Why is high homology-directed repair important?. , 4.5 Applicability of CRISPR beyond just simple editing -- 4.5.1 CRISPR screens -- 4.5.2 CRISPR without double-stranded breaks -- 4.5.3 Gene Silencing through CRISPR interference (CRISPRi) -- 4.5.4 Gene activation (CRISPRa) -- 4.5.5 Anti-CRISPR -- 4.5.6 Nonediting functions with dCas9 comprising of RNP -- 4.5.7 Gene visualizations -- 4.6 Conclusions and future perspectives -- References -- 5 Molecular engineering of CRISPR-Cas system toward in vitro diagnostics -- 5.1 Introduction -- 5.2 Historical developments -- 5.3 CRISPR-Cas-mediated sensing of nucleic acid targets -- 5.3.1 DNA -- 5.3.2 RNA -- 5.4 CRISPR-Cas-mediated sensing of nonnucleic-acid targets -- 5.4.1 Proteins -- 5.4.2 Enzyme activity -- 5.4.3 Small organic compounds and metal ions -- 5.5 Challenges -- 5.6 Conclusions -- References -- 6 The CRISPR-Cas technology: trends in healthcare -- 6.1 Introduction -- 6.2 Overview of the CRISPR-Cas system -- 6.3 Historical Background -- 6.4 Emerging applications of CRISPR-Cas systems in healthcare -- 6.4.1 Disease diagnosis -- 6.4.2 Genome-scale screening -- 6.4.3 Typing of bacterial strains -- 6.4.4 Antimicrobial tool: targeting drug resistance and microbial pathogens -- 6.4.5 Genome editing tools in therapeutics -- 6.4.6 Antiviral therapies -- 6.5 Potential of CRISPR-based therapeutics in various diseases and disorders -- 6.5.1 Infectious diseases -- 6.5.2 Genetic disorders -- 6.5.2.1 Monogenic disorders -- 6.5.2.1.1 Cystic fibrosis -- 6.5.2.1.2 Sickle cell anemia -- 6.5.2.1.3 β-thalassemia -- 6.5.2.1.4 Duchenne muscular dystrophy -- 6.5.2.1.5 Hemophilia -- 6.5.2.2 Multifactorial diseases -- 6.5.2.2.1 Diabetes -- 6.5.2.2.2 Cardiovascular disease -- 6.5.2.2.3 Cancer -- 6.6 CRISPR-Cas9 for developing disease models -- 6.7 Drug target discovery -- 6.8 CRISPR babies: ethical or unethical -- 6.9 Conclusions -- References. , 7 CRISPR-Cas system and its role in the development of viral disease diagnostics -- 7.1 Introduction -- 7.2 CRISPR-Cas in a snapshot -- 7.3 CRISPR-Cas-based diagnostics -- 7.3.1 NASBA-CC -- 7.3.1.1 Functioning of toehold switches -- 7.3.1.2 Zika and toehold switches -- 7.3.1.3 CRISPR-Cas9 with NASBA and toehold switch -- 7.3.2 DETECTR -- 7.3.3 HOLMES -- 7.3.4 SHERLOCK (Specific High Sensitivity Enzymatic Reporter Unlocking) -- 7.3.5 HUDSON -- 7.3.6 FELUDA -- 7.3.7 E-CRISPR -- 7.3.8 CRISDA -- 7.4 Conclusions -- References -- 8 Unlocking new ways to tackle tuberculosis using CRISPR-Cas as a potent weapon -- 8.1 Introduction to tuberculosis -- 8.1.1 Epidemiology of tuberculosis -- 8.1.2 Mechanism of pathogenesis -- 8.1.3 Virulence of M. tuberculosis -- 8.2 Essentiality of tools for tackling tuberculosis -- 8.2.1 Expected increase in tuberculosis cases due to effect of COVID pandemic -- 8.2.2 Drug-resistant tuberculosis -- 8.3 CRISPR and tuberculosis -- 8.3.1 CRISPR systems in M. tuberculosis -- 8.3.2 CRISPR technology for genetic engineering -- 8.4 Applications of CRISPR in tackling tuberculosis -- 8.4.1 In functional genomic screening -- 8.4.2 In tackling drug resistance -- 8.4.3 In identification of virulent genes as potential drug targets -- 8.4.4 In diagnosis of tuberculosis -- 8.5 Conclusions and future perspectives -- References -- 9 Application of CRISPR-Cas in disease diagnosis and management -- 9.1 Introduction -- 9.2 Diagnosis of infectious diseases by CRISPR-Cas system -- 9.2.1 Detection of pathogens by CRISPR-Cas system -- 9.2.1.1 CRISPR-based lateral flow assays -- 9.2.1.2 Fluorescence-based diagnostic kits -- 9.3 Diagnosis of noninfectious agents by CRISPR-Cas system -- 9.4 CRISPR-Cas system for animal and cell models -- 9.5 CRISPR-Cas system for diagnosis of plant disease -- 9.6 Challenges and future perspectives -- References. , 3 CRISPR-Cas in environmental biotechnology -- 10 Environmental metagenomics and CRISPR-Cas -- 10.1 Introduction -- 10.2 CRISPR in the investigation of different microbiomes -- 10.2.1 Agricultural microbiome -- 10.2.2 Environmental microbiome -- 10.2.3 Oral microbiome -- 10.2.4 Gut microbiome -- 10.3 Anti CRISPRs -- 10.4 Conclusions and future perspective -- References -- 11 CRISPR systems tackling fungal infections -- 11.1 Introduction -- 11.2 CRISPR in Candida -- 11.3 CRISPR in Cryptococcus species complex -- 11.4 CRISPR in Aspergillus fumigatus -- 11.5 Conclusions -- References -- 4 CRISPR-Cas in food and agriculture biotechnology -- 12 CRISPR-Cas technologies in food security and food revolution -- 12.1 Introduction -- 12.2 What is CRISPR-Cas-an insight -- 12.3 Applications and limitations of the CRISPR-Cas system -- 12.4 CRISPR-Cas in agriculture -- 12.5 CRISPR-Cas in food processing and technology -- 12.6 Conclusions -- References -- 13 Overview of the genome editing in rice and its implications -- 13.1 Introduction -- 13.2 Technologies for genome editing in rice -- 13.2.1 CRISPR Cas9-based editing -- 13.2.2 Multiplex genome editing -- 13.2.3 CRISPR-Cas12a/Cpf1 -- 13.2.4 Zinc-finger nucleases (ZFNs) -- 13.2.5 TALENs -- 13.2.6 Base editing -- 13.3 Safety concerns -- 13.3.1 Risks to the health of humans and animals -- 13.3.2 Environmental issues -- 13.3.3 Public concerns -- 13.3.4 Transgene-free editing of rice -- 13.4 Conventional methods for transgene removal -- 13.4.1 Transient expression of CRISPR-Cas9 machinery -- 13.4.2 Suicide transgene -- 13.4.3 Fluorescence-based technology -- 13.4.4 CRISPR-Cas9 ribonucleoproteins -- 13.5 Conclusions -- References -- 14 Biotechnological applications of CRISPR-Cas systems in fungi -- 14.1 Introduction -- 14.2 An historical overview of CRISPR-Cas technological advancements in fungal research. , 14.3 CRISPR-Cas systems in fungi of biotechnological importance.

Additional Edition: Print version: Joshi, Swati CRISPR-Cas System in Translational Biotechnology San Diego : Elsevier Science & Technology,c2023 ISBN 9780323918084

Language: English

UID:

Format: 1 online resource (xix, 449 pages) : , illustrations

ISBN: 1000281582 , 9781003124160 , 100312416X , 9781000281644 , 1000281647 , 9781000281705 , 1000281701 , 9781000281583

Series Statement: Routledge literature companions

Content: "In recent years, Australian literature has experienced a revival of interest both domestically and internationally. The increasing prominence of work by writers like Christos Tsiolkas, heightened through television and film adaptation, as well as the award of major international prizes to writers like Richard Flanagan, and the development of new, high-profile prizes like the Stella Prize, have all reinvigorated interest in Australian literature both at home and abroad. This Companion emerges as a part of that reinvigoration, considering anew the history and development of Australian literature and its key themes, as well as tracing the transition of the field through those critical debates. It considers works of Australian literature on their own terms, as well as positioning them in their critical and historical context and their ethical and interactive position in the public and private spheres. With an emphasis on literature's responsibilities, this book claims Australian literary studies as a field uniquely positioned to expose the ways in which literature engages with, produces and is produced by its context, provoking a critical re-evaluation of the concept of the relationship between national literatures, cultures, and histories, and the social function of literary texts."--

Note: Introduction: Australian literature, companionship, and viral responsibility / Jessica Gildersleeve. Literature in the colony. Expressing a new civilisation : authorship, publishing, and reading in the 1890s / Roger Osborne ; The redemption of the larrikin at the turn of the twentieth century / Michelle J. Smith ; The metropolis or the bush? / Megan Brown ; The weeping kangaroo / Ken Gelder and Rachael Weaver -- Early twentieth-century Australia. The reflective moment : modernity in early twentieth-century Australia / Susan Carson ; Among the autumn authors : books and writers in interwar Australian magazines / Sarah Galletly and Victoria Kuttainen ; "Caterpillars of the Commonwealth" : dangerous books in Australia / Francesca Rendle-Short ; "Mad, muddy, mess of eels" : modern theatre and Patrick White's sensuous dramaturgy / Janet McDonald -- Contemporary Australia. "Are you with me?" : offensiveness and Australian drama in the 1970s / Julian Meyrick and Jenny Fewster ; Around 1988 : Australian literature, history, and the bicentenary / Eduardo Marks de Marques ; Politics and contemporary Australian fiction / Nicholas Birns ; Towards a new direction in contemporary criticism : cognitive Australian literary studies / Jean-François Vernay -- Australian literary studies in the public sphere. Literary criticism in Australia / Emmett Stinson ; Obstetric realism and sacred cows : women writers and book reviewing in Australia / Melinda Harvey and Julieanne Lamond ; Literary prizes and the public sphere / Alexandra Dane ; Literary media entertainment : author stardom and the public (media) sphere / Della Robinson ; Australian literature in the university / Leigh Dale ; An Australian ethics of reading? / Maggie Nolan -- Australian literature and the world. News from Australia : global modernism studies and the case of Australian modernism / Melinda J. Cooper ; Hijabi-bodies and sartorial strategies / Devaleena Das ; Australian literature in Asia : China and India / David Carter and Paul Sharrad ; Facing east : Asia in Australian literature / David Walker -- Key themes in Australian writing. Turning the inside out : interiority and Australian fiction / Peter D. Mathews ; Gendering Australian literature / Alison Bartlett ; "Silence is my habitat" : Judith Wright, writing, and deafness / Jessica White ; Asylum seekers and refugees in Australian literature / Daniel Hourigan ; Into the urban labyrinth : Helen Garner and the drug narrative / Nycole Prowse ; "Something new at hand" : Australian literature and the sacred / Lyn McCredden ; Animal presence : problems and potential in recent Australian fiction / Clare Archer-Lean ; Landscape (after Mabo) / Tony Hughes d'Aeth ; "The extraordinary behind the ordinary" : a brief history of Australian suburban literature / Nathanael O'Reilly ; Australian literature and everyday life / Andrew McCann ; Emblematic spaces : postcoloniality and the region / Stephanie Green -- Genre in Australian literary studies. Twenty-first-century Australian poetry / Sarah Holland-Batt and Ella Jeffery ; Life writing and conflict : love wins / Kylie Cardell and Kate Douglas ; Reluctant wandering : new mobilities in contemporary Australian travel writing / Kate Cantrell ; Australia's long relationship with romance / Tanya Dalziell ; Magical migrations : Australian fairy tale traditions and practices / Nike Sulway ; Shadows in paradise : Australian gothic / Gina Wisker ; Australian television and literary criticism / Susan Lever ; Screen adaptation and Australian literature / Karina Aveyard.

Additional Edition: Print version: Routledge companion to Australian literature. New York, NY : Routledge, [2021] ISBN 0367643561

Language: English

Subjects: English Studies

Keywords: Electronic books. ; Electronic books. ; Criticism, interpretation, etc. ; Aufsatzsammlung

URL: https://www.taylorfrancis.com/books/9781003124160

URL: lizenzpflichtig

UID:

Format: 1 online resource (XI, 319 p. 50 illus., 41 illus. in color.)

Edition: 3rd ed. 2018.

ISBN: 1-4939-7601-X

Series Statement: Methods in Molecular Biology, 1733

Content: This volume focuses on the analysis of miRNA and its many components such as targets and expression profiling, regulation of gene expression, miRNA detection in biofluids, and its application in cancer and wound healing. The chapters in this book explore topics that’s cover biogenesis, isolation and profiling of miRNA, exosomal miRNAs, and the study of the functional significance of miRNAs. The chapters also cover screening miRNAs in mR-302/367 induced iPSCs, exosomal miRNAs from iPSC-derived cardiomyocytes proliferation, and the recently discovered sugar-like RNA glycylglycerins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, MicroRNA Protocols, Third Edition is a valuable resource that provides researchers with a comprehensive study of miRNAs and its numerous components and uses.

Note: The MicroRNA.- Target mRNA Driven Biogenesis of Cognate MicroRNAs In Vitro.- Isolation of Viral-Infected Brain Regions for miRNA Profiling from Formalin-Fixed Paraffin-Embedded Tissues by Laser Capture Microdissection .- Isolation and Analysis of Exosomal Microsomal MicroRNAs from Ovarian Follicular Fluid.- Profiling of MicroRNAs in the Biofluids of Livestock Species.- Exosomal MicroRNAs as Potential Biomarkers in Neuropsychiatric Disorders -- Identification and Validation of Potential Differential miRNA Regulation via Alternative Polyadenylation.- How to Explore the Function and Importance of MicroRNAs: MicroRNAs Expression Profile and their Target/Pathway Prediction in Bovine Ovarian Cells.- Gene Silencing In Vitro and In Vivo using Intronic MicroRNAs.- Mining Exosomal MicroRNAs from Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes for Cardiac Regeneration.- Quantitative Analysis of Precursors MicroRNAs and their Respective Mature MicroRNAs in Cancer Exosomes Overtime.- Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets -- In Vitro Methods for Analyzing miRNA Roles in Cancer Cell Proliferation, Invasion,  and Metastasis.- Isolation and Identification of Gene-Specific MicroRNAs.- Comprehensive Measurement of Gene Silencing Involving Endogenous MicroRNAs in Mammalian Cells -- Screening miRNA for Functional Significance by 3D Cell Culture System.- Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs.- Neonatal Rat Cardiomyocytes Isolation, Culture and Determination of MicroRNAs’ Effects in Proliferation.- Gene Manipulation with Micro RNAs at Single Human Cancer Cell.- Laser Capture Microdissection of Epithelium from a Wound Healing Model for MicroRNA Analysis.- Transgene-Like Animal Models Using Intronic MicroRNAs -- Application of TALE-Based Approach for Dissecting Functional MicroRNA-302/367 in Cellular Reprogramming.- Mechanism and Method for Generating Tumor-Free iPS Cells Using Intronic MicroRNA miR302 Induction.- The miR-302-Mediated Induction of Pluripotent Stem Cells (iPSC): Multiple Synergistic Reprogramming Mechanisms.- Identification and Isolation of Novel Sugar-Like RNA Protecting Materials Glycylglycerins from Pluripotent Stem Cells.

Additional Edition: ISBN 1-4939-7600-1

Language: English

DOI: 10.1007/978-1-4939-7601-0

UID:

Format: 1 online resource (779 p.)

Edition: 3rd ed.

ISBN: 1-4377-1099-9

Content: Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new

Note: Description based upon print version of record. , Front Cover; The Molecular Basis of Cancer; Copyright Page; List of Contributing Authors; Preface; Contents; Part I: Carcinogenesis and Cancer Genetics; Chapter 1. Cancer: A Genetic Disorder; The Discovery of Cellular Oncogenes; Multistep Tumorigenesis; The Discovery of Tumor Suppressor Genes; Guardians of the Genome; Epigenetic Mechanisms Leading to Loss of Gene Function; Immortalized Proliferation; Nongenetic Mechanisms Accelerating Multistep Tumor Progression; Invasive and Metastatic Behaviors; Other Phenotypes of Neoplasia; References; Chapter 2. Oncogenes and Signal Transduction , Signaling: An OverviewOncogenes; Signal Transduction by Protein Tyrosine Kinase Receptors; Signaling Pathways of Tyrosine Kinase Receptors; Oncogenes and Survival Signaling; Cytokine Receptor Signaling; Neurotransmitters; Wnt Signaling; Implications for Cancer Therapy; References; Chapter 3. Tumor Suppressor Genes; The Concept of Tumor Suppressor Genes; The Tumor Suppressor Genes; The p53-Rb Pathway Interconnections; The Interconnections of the p53 and the IGF-1-mTOR Pathways; Conclusion; References; Chapter 4. DNA Repair Pathways and Human Cancer; The Spectrum of DNA Damage; DNA Repair , The Systematic Study of DNA RepairDNA Repair and the DNA Damage Response; Inherited Chromosome Instability Syndromes as Models for DNA Repair Defects; Somatic Disruption of DNA Repair Pathways by Methylation and Gene Silencing; Prognostic and Predictive DNA Repair Biomarkers in Cancer Treatment; Development of new DNA Repair Biomarkers; Multiple Mechanisms of Cisplatin Resistance; Conclusion; References; Chapter 5. Epigenetics and Cancer; The Molecular Basis for Epigenetic Control of Gene Expression; Abnormalities of DNA Methylation and Chromatin Organization in Cancer: the Cancer "Epigenome" , Relationships of Epigenetic Changes in General, and Aberrant Gene Silencing in Particular, to the Progression of CancerTranslational Implications of Epigenetic Changes in Cancer; References; Chapter 6. Infectious Agents and Cancer; Overview of Cancer and Infectious Agents; Viruses and Cancer; Bacteria and Cancer; Parasites and Cancer; Perspectives; References; Chapter 7. Environmental Carcinogenesis; Introduction to Cancer and the Environment; Causes of Cancer; Classes and Types of Carcinogens; Mechanisms of Chemical Carcinogenesis; Ecogenetics and Cancer Risk; Cancer Prevention , Summary and ConclusionsReferences; Chapter 8. Animal Models Flies, Fish, and Yeast; Why Use a Simple Model Organism?; Genetic Conservation and Synteny; Forward Genetics, Reverse Genetics, and Transgenesis; Drug Screens; Conditional Models; Yeast; Flies; Fish; Conclusion; References; Chapter 9. Genetic Mouse Models of Cancer; Basis for Mouse Models of Cancer; Mouse Models of Cancer; Techniques to Modify the Mouse Genome; Applications of Mouse Models to Cancer Biology; Future Directions of Cancer Models; Conclusions; References; Part II: Cancer Biology; Chapter 10. Cancer Stem Cells , Not All Cancer Cells are Created Equal , English

Additional Edition: ISBN 1-4160-3703-9

Language: English

UID:

Format: 1 online resource (XI, 218 p. 9 illus. in color.)

Edition: 1st ed. 2016.

ISBN: 1-4939-3148-2

Series Statement: Methods in Molecular Biology, 1372

Content: This detailed volume will focus on the phenomenon of RNA interference by providing comprehensive coverage of various techniques for in vivo micro/siRNA imaging including the design and synthesis of specific imaging agents and tools, the development of imaging methodologies, and their interpretation. An essential element in the development and optimization of these therapies is the ability to measure the bioavailability and functionality of the RNA/oligonucleotide molecule after administration into the body. Noninvasive imaging provides the necessary set of tools to accomplish this in authentic physiologic environments and across time. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and practical, RNA Imaging: Methods and Protocols serves physicians, scientists, and graduate students who are either new to the field of RNA-based imaging and its associated therapeutic applications or who wish to be apprised of recent advances in the state of the art.

Note: Bibliographic Level Mode of Issuance: Monograph , Imaging Functional Nucleic Acid Delivery to Skin -- In Vivo Magnetic Resonance Imaging of Small Interfering RNA Nanodelivery to Pancreatic Islets -- Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy -- Targeted Delivery with Imaging Assessment of siRNA Expressing Nanocassettes into Cancer -- Analyses of Tumor Burden In Vivo and Metastasis Ex Vivo Using Luciferase-Expressing Cancer Cells in an Orthotopic Mouse Model of Neuroblastoma -- Indium-Labeling of siRNA for Small Animal SPECT Imaging -- Imaging of Electrotransferred siRNA -- Whole-Body Scanning PCR, a Tool for the Visualization of the In Vivo Biodistribution Pattern of Endogenous and Exogenous Oligonucleotides in Rodents -- siRNA Nanoparticles for Ultra-Long Gene Silencing In Vivo -- Sensing miRNA: Signal Amplification by Cognate RISC for Intracellular Detection of miRNA in Live Cells -- Molecular Beacon-Based MicroRNA Imaging During Neurogenesis -- Hypoxia-Responsive Copolymer for siRNA Delivery -- Controlling RNA Expression in Cancer Using Iron Oxide Nanoparticles Detectable by MRI and In Vivo Optical Imaging -- Microvesicles: Isolation, Characterization for In Vitro and In Vivo Procedures -- Positive Bioluminescence Monitoring of MicroRNA Expression in Small Animal Models Using an Engineered Genetic-Switch Expression System, RILES -- MicroRNA Imaging in Combination with Diagnostic Ultrasound and Bubble Liposomes for MicroRNA Delivery. , English

Additional Edition: ISBN 1-4939-3147-4

Language: English

Keywords: Laboratory Manuals ; Laboratory Manuals ; Laboratory Manuals ; Laboratory Manuals

DOI: 10.1007/978-1-4939-3148-4