UID:
almafu_9959328336002883
Umfang:
1 online resource
ISBN:
9781118349069
,
1118349067
,
9781118349038
,
1118349032
,
9781118349052
,
1118349059
,
9781118349045
,
1118349040
,
111997609X
,
9781119976097
,
9781283592741
,
1283592746
Inhalt:
Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases; DNA methylation and toxicogenomics; chromatin at the intersection of disease and therapy; epigenomic actions of environmental arsenicals; environment, epigenetics and cardiovascular health; toxicology, epigenetics and autoimmunity; ocular epigenomics: potential sites of environmental impact in development and disease〈; nuclear RNA silencing and related phenomena in animals; epigenomics - impact for drug safety sciences; methods of global epigenomic profiling; transcriptomics: applications in epigenetic toxicology. Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.
Anmerkung:
Environment, Epigenetics and Diseases / Robert Y.S. Cheng and Wan-yee Tang -- DNA Methylation and Toxicogenomics / Deepti Dileep Deobagkar -- Chromatin at the Intersection of Disease and Therapy / Delphine Quénet, Marcin Walkiewicz and Yamini Dalal -- Molecular Epigenetic Changes Caused by Environmental Pollutants / Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. Sepulveda -- Epigenetic mediation of environmental exposures to Polycyclic Aromatic Hydrocarbons / Bekim Sadikovic and David I. Rodenhiser -- Epigenomic Actions of Environmental Arsenicals / Paul L. Severson & Bernard W. Futscher -- Arsenic-induced Changes to the Epigenome / Kathryn A. Bailey and Rebecca C. Fry -- Environmental Epigenetics, Asthma and Allergy : Our environment's Molecular Footprints / Stephanie Lovinsky-Desir and Rachel L. Miller -- miRNAs in Human Prostate Cancer / Ernest K. Amankwah and Jong Y. Park -- Environment, Epigenetics and Cardiovascular Health / Sanjukta Ghosh and Andrea Baccarelli -- Toxicology, Epigenetics and Autoimmunity / Craig A. Cooney and Kathleen M. Gilbert -- Toxicoepigenomics in Lupus / Donna Ray and Bruce C. Richardson -- Ocular Epigenomics : Potential Sites of Environmental Impact in Development and Disease / Kenneth P. Mitton -- Nuclear RNA Silencing and Related Phenomena in Animals / Radek Malik and Petr Svoboda -- Epigenetic Biomarkers in Cancer Detection and Diagnosis / Ashley G. Rivenbark and William B. Coleman -- Epigenetic Histone Changes in the Toxicologic mode of action of Arsenic / John F. Reichard and Alvaro Puga.
,
Irreversible Effect of Diethylstilbestrol on Reproductive Organs and Current Approach for Epigenetic Effects of Endocrine Disrupting Chemicals / Shinichi Miyagawa, Ryohei Yatsu, Tamotsu Sudo, Katsuhide Igarashi, Jun Kanno, and Taisen Iguchi -- Epigenomics : Impact for Drug Safety Sciences / Harri Lempiäinen, Raphaelle Luisier, Arne Muller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs, and Rémi Terranova -- Archival Toxicoepigenetics : Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies / B. Alex Merrick -- Nanoparticles and Toxicoepigenomics / Manasi P. Jain, Angela O. Choi, and Dusica Maysinger -- Methods of Global Epigenomic Profiling / Michael W.Y. Chan, Zhengang Peng, Jennifer R. Chao, Yingwei Li, Matthew T. Zuzolo, and Huey-Jen L. Lin -- Transcriptomics : Applications in Epigenetic Toxicology / Pius Joseph -- Carcinogenic metals alter histone tail modifications / Yana Chervona and Max Costa -- Prediction of epigenetic and stochastic gene expression profiles of late effects after radiation exposure / Yoko Hirabayashi and Tohru Inoue -- Modulation of developmentally regulated gene expression programs through targeting of polycomb and trithorax group proteins / Marjorie Brand and F. Jeffrey Dilworth -- Chromatin Insulators and Epigenetic Inheritance in Health and Disease / Jingping Yang and Victor G. Corces -- Bioinformatics for High-Throughput Toxico-epigenomics Studies / Maureen A. Sartor, Dana C. Dolinoy, Laura S. Rozek, and Gilbert S. Omenn -- Computational Methods in Toxicoepigenomics / Joo Chuan Tong -- Databases and Tools for Computational Epigenomics / V. Umashankar and S. Gurunathan -- Interface of Epigenetics and Carcinogenic Risk Assessment / Paul Nioi -- Epigenetic Modifications in Chemical Carcinogenesis / Igor P. Pogribny, Igor Koturbash, and Frederick A. Beland -- Application of Cancer Toxicoepigenomics in Identifying High-Risk Populations / Mukesh Verma and Krishna K Banaudha.
Weitere Ausg.:
Print version: Toxicology and epigenetics. Chichester, West Sussex, U.K. ; Hoboken, N.J. : John Wiley & Sons, 2012 ISBN 9781119976097
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118349045
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118349045
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118349045
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