Format:
Online-Ressource (IX, 518 p. 70 illus., 39 illus. in color, digital)
ISBN:
9789400745759
Series Statement:
SpringerLink
Content:
Cancer still remains a most important killer and even though synthetic chemotherapeutic agents are currently used, they are cost-intensive and do not always meet the expectations. In parallel, there is increasing evidence for the potential of nature-derived compounds on the inhibition of different steps of cancer initiation, promotion and progression. We believe that all diseases can be found in Nature but that Nature also provides the efficient cures as said the Prophet of Allah: "Allah did not create any illness without also creating the remedy. The content of this book gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases. The cell death inducing mechanisms (apoptosis, anti-proliferative activity, angiogenesis, cell cycle control, cytostatic property and autophagy) give an overview of how natural products are able to target cancer cells. We believe that all diseases can be found in Nature but that Nature also provides the efficient cures as said the Prophet of Allah: "Allah did not create any illness without also creating the remedy. The content of this book gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases. The cell death inducing mechanisms (apoptosis, anti-proliferative activity, angiogenesis, cell cycle control, cytostatic property and autophagy) give an overview of how natural products are able to target cancer cells.
Note:
Description based upon print version of record
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Natural Compounds as Inducers of Cell Death; Editorial; Natural Products Research in the Greater Saar-Lor-Lux Region: Corena; Contents; Part I Phytochemicals as Inducers of Cell Death Mechanisms; Chapter 1: Phytochemicals and Amino Acids: Inducers or Inhibitors of Cell Death?; 1.1 Phytochemicals; 1.1.1 Terminology, Definition and Classification; 1.1.2 Phytochemicals as Cancer Chemopreventive Agents; 1.1.2.1 Mechanisms of Cancer Prevention by Phytochemicals; 1.1.2.2 Phytochemicals as Inducers of Cell Death; 1.1.2.3 Phytochemicals as Inhibitors of Cell Death
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1.1.2.4 Phytochemicals as Redox Active Compounds with Dual Effects1.1.3 Cytotoxic Phytochemicals Are Cytoprotective to Normal Cells; 1.1.4 Toxic Phytochemicals as Chemoprotective Agents; 1.1.5 Curcumin; 1.1.5.1 Mechanisms of Anti-cancer Activity; 1.1.5.2 Mechanisms of Apoptosis Induction; 1.1.5.3 Curcumin Protects Against Cell Death; 1.1.6 Astragalus; 1.1.6.1 History and Origin; 1.1.6.2 Chemistry; 1.1.6.3 Pharmacology; Protective Effects of Astragalus; Cytotoxic Activities of Astragalus; 1.1.6.4 Egyptian Astragalus Species; Pharmacology; Chemistry; Selected Example of Egyptian Astragalus
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1.2 Amino Acids1.2.1 Introduction; 1.2.2 Amino Acids as Inducers of Cell Death; 1.2.2.1 Excitatory Amino Acids and Cell Death; Excitotoxicity and Apoptosis; Glycine as an Excitatory Co-transmitter; Excitatory Amino Acids as Inhibitors of Cell Death; 1.2.2.2 Branched-Chain Amino Acids and Cell Death; 1.2.3 Cytoprotective Effects of Amino Acids; 1.2.3.1 Amino Acids as Anti-apoptotic Agents; 1.2.3.2 Amino Acids as Osmolytes; 1.2.3.3 Amino Acids as Chemoprotective Inhibitors of Cell Death; 1.2.4 N-Acetylcysteine and Cysteine; 1.2.5 Glycine; 1.2.5.1 The Receptors; 1.2.5.2 Anti-cancer Activity
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1.2.5.3 Protective Effects1.2.5.4 Protective Mechanisms; Gly and Cell Death; Gly and Ion Channels; Gly and GSH; Gly and Lipid Peroxidation; Gly as a Membrane Stabilizer; 1.3 Concluding Remarks; References; Chapter 2: Pomegranate-Derived Constituents as Inducers of Cell Death: Implications in Cancer Prevention and Therapy; 2.1 Introduction; 2.2 Apoptosis; 2.3 Pomegranate; 2.3.1 The Tree and the Fruit; 2.3.2 Chemical Constituents; 2.3.3 Pomegranate and Cancer; 2.3.4 Bioavailability, Toxicity and Synergy of Pomegranate Constituents; 2.4 Pomegranate-Mediated Apoptotic and Anti-cancer Effects
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2.4.1 In Vitro and In Vivo Studies2.4.1.1 Breast Cancer; 2.4.1.2 Colon Cancer; 2.4.1.3 Hematological Cancer; 2.4.1.4 Skin Cancer; 2.4.1.5 Prostate Cancer; 2.4.1.6 Liver Cancer; 2.5 Conclusion and Future Directions; References; Chapter 3: Antitumor Effects of Anthocyanins: Focus on Apoptosis; 3.1 Introduction; 3.2 Chemistry of Anthocyanins; 3.3 Modulation of Apoptosis by Anthocyanins; 3.3.1 In Vitro Studies; 3.3.1.1 Induction of Apoptosis; 3.3.1.2 Inhibition of Apoptosis; 3.3.2 In Vivo Studies on Animals; 3.3.2.1 Induction of Apoptosis; 3.3.2.2 Inhibition of Apoptosis; 3.4 Conclusions
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References
Additional Edition:
ISBN 9789400745742
Additional Edition:
Buchausg. u.d.T. ISBN 978-94-007-4574-2
Language:
English
DOI:
10.1007/978-94-007-4575-9
URL:
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