In:
Chemistry & Biodiversity, Wiley, Vol. 15, No. 1 ( 2018-01)
Kurzfassung:
As natural‐product‐derived antibiotics, desotamides A – D and wollamides exhibit growth inhibitory activity against Gram ‐posivite bacteria ( IC 50 0.6 – 7 μ m ) and are noncytotoxic to mammalian cells ( IC 50 〉 30 μ m ). Herein we firstly report the total synthesis of above two cyclohexapeptides as well as a series of structural variants through solid phase peptide synthesis, of which 3 displayed a 2‐fold increase of antibacterial activity when compared with the original peptide 1 . This strategy may offer good improvements for the synthesis of other cyclic peptides.
Materialart:
Online-Ressource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201700414
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2139001-0
SSG:
12