In:
Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2022-7-1)
Kurzfassung:
In the zebrafish lateral line system, interneuromast cells (INCs) between neuromasts are kept quiescent by underlying Schwann cells (SWCs). Upon severe injuries that cause the complete loss of an entire neuromast, INCs can occasionally differentiate into neuromasts but how they escape from the inhibition by SWCs is still unclear. Using a genetic/chemical method to ablate a neuromast precisely, we found that a small portion of larvae can regenerate a new neuromast. However, the residual regeneration capacity was hindered by inhibiting macrophages. Using in toto imaging, we further discovered heterogeneities in macrophage behavior and distribution along the lateral line. We witnessed the crawling of macrophages between the injured lateral line and SWCs during regeneration and between the second primordium and the first mature lateral line during development. It implies that macrophages may physically alleviate the nerve inhibition to break the dormancy of INCs during regeneration and development in the zebrafish lateral line.
Materialart:
Online-Ressource
ISSN:
2296-634X
DOI:
10.3389/fcell.2022.907863
DOI:
10.3389/fcell.2022.907863.s001
DOI:
10.3389/fcell.2022.907863.s002
DOI:
10.3389/fcell.2022.907863.s003
DOI:
10.3389/fcell.2022.907863.s004
DOI:
10.3389/fcell.2022.907863.s005
DOI:
10.3389/fcell.2022.907863.s006
DOI:
10.3389/fcell.2022.907863.s007
DOI:
10.3389/fcell.2022.907863.s008
DOI:
10.3389/fcell.2022.907863.s009
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2022
ZDB Id:
2737824-X