In:
FEBS Letters, Wiley, Vol. 590, No. 24 ( 2016-12), p. 4606-4616
Abstract:
Development of targeted therapies for triple‐negative breast cancer ( TNBC , a more aggressive subtype) is an unmet medical need. We analyzed data from 887 patients with invasive breast cancer and observed that increased Wnt and histone deacetylase ( HDAC ) activities are associated with estrogen receptor 1 ( ESR 1) and progesterone receptor ( PGR ) repression, poor survival, and increased relapse. The inverse correlation between Wnt signaling and repression of ESR 1 and PGR expression was found to be magnified in cancer stem cell ( CSC ) subpopulations in TNBC cell lines. Cosuppression of Wnt, HDAC , and ESR 1 using clinically relevant low‐dose inhibitors effectively repressed both bulk and CSC subpopulations and converted CSC s to non‐ CSC s in TNBC cells without affecting MCF ‐10A mammary epithelial cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2016.590.issue-24
DOI:
10.1002/1873-3468.12496
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1460391-3
SSG:
12
