In:
FEBS Letters, Wiley, Vol. 592, No. 6 ( 2018-03), p. 949-961
Kurzfassung:
We show that glioblastoma multiform (GBM) cells overexpressing the constitutively active form of the epidermal growth factor receptor [epidermal growth factor receptor variant III ( EGFR v III ) and U87 MG human GBM cell line overexpressing EGFR v III ( EGFR +) cells] possess greater invasive properties and have higher levels of extracellular sphingosine‐1‐phosphate (S1P) and increased sphingosine kinase‐1 ( SK 1) activity than the empty vector‐expressing cells. Notably, the inhibition of SK 1 or S1P receptors decreases the invasiveness of EGFR + cells. Moreover, EGFR and MEK 1 inhibitors reduce both SK 1 activation and cell invasion, suggesting that the enhanced invasiveness observed in the EGFR + cells depends on the increased S1P secretion, downstream of the EGFR v III ‐ ERK ‐ SK 1‐S1P pathway. Altogether, the results of the present study indicate that, in GBM cells, EGFR v III is connected with the S1P signaling pathway to enhance cell invasiveness and tumor progression.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2018.592.issue-6
DOI:
10.1002/1873-3468.13000
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
1460391-3
SSG:
12