In:
FEBS Letters, Wiley, Vol. 593, No. 18 ( 2019-09), p. 2556-2565
Kurzfassung:
Nuclear receptor‐binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown. In this study, we found that NSD3 expression is reduced by isoproterenol (ISO) stimuli both in vitro and in vivo . Overexpression of NSD3 attenuates ISO‐induced cardiomyocyte hypertrophy. Mechanistically, ISO treatment decreases H3K27me2/3 modifications on the atrial natriuretic factor (ANF) promoter by suppressing NSD3 and inhibits the association between NSD3 and bromodomain‐containing protein 4 (BRD4), thus suppressing the BRD4‐mediated H3K27ac modifications, which ultimately promote ANF transcription and cardiomyocyte hypertrophy. In conclusion, NSD3 decreases ANF expression and, thereby, attenuates ISO‐induced cardiomyocyte hypertrophy.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.v593.18
DOI:
10.1002/1873-3468.13515
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
1460391-3
SSG:
12