In:
FEBS Letters, Wiley, Vol. 597, No. 1 ( 2023-01), p. 166-173
Abstract:
Biological redox reactions often use a set‐up in which final redox partners are localized in different compartments and electron transfer (ET) among them is mediated by redox‐active molecules. In enzymes, these ET processes occur over nm distances, whereas multi‐protein filaments bridge μm ranges. Electrons are transported over cm ranges in cable bacteria, which are formed by thousands of cells. In this review, we describe molecular mechanisms that explain how respiration in a compartmentalized set‐up ensures redox homeostasis. We highlight mechanistic studies on ET through metal‐free peptides and proteins demonstrating that long‐distance ET is possible because amino acids Tyr, Trp, Phe, and Met can act as relay stations. This cuts one long ET into several short reaction steps. The chances and challenges of long‐distance ET for cellular redox reactions are then discussed.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/1873-3468.14493
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1460391-3
SSG:
12