In:
Arthritis Care & Research, Wiley, Vol. 67, No. 10 ( 2015-10), p. 1481-1486
Abstract:
To explore whether baseline to 12‐month followup change in femorotibial cartilage thickness differs between subjects who received a total knee arthroplasty (TKA) between 24 and 60 months from those without TKA (non‐TKA). Methods In this prospective cohort study, 531 right knees from Osteoarthritis Initiative participants with definite radiographic knee osteoarthritis (Kellgren/Lawrence [K/L] grades 2–4) were studied. Segmentation was applied to coronal fast low‐angle shot magnetic resonance images, to quantitatively determine cartilage thickness in 16 femorotibial subregions. Unadjusted P values ( t ‐tests) and P values adjusted for age, baseline body mass index (BMI), K/L grade, and sex (generalized estimating equation models) were used to evaluate differences in longitudinal 1‐year rates of cartilage thickness between TKAs and non‐TKAs, with total knee arthroplasty status as fixed effect. Results Of the 531 participants (mean ± SD ages 63 ± 9 years, BMI 30 ± 4.8 kg/m 2 ), 40 received a femorotibial TKA within 4 years. At baseline, TKAs had thinner medial and lateral femorotibial cartilage (−15%; P 〈 0.001) than non‐TKAs. Longitudinal cartilage thickness change was significantly greater in TKAs than in non‐TKAs in the total femorotibial joint (area under the curve [AUC] 0.64), the lateral compartment (AUC 0.66), both tibiae (AUC ≥ 0.61), and the first 9 (of 16) ordered values of subregion change (AUC 0.64–0.69). Discrimination was stronger for TKAs that occurred at 24 and 36 months (n = 18) than for those at 48 and 60 months (n = 22). Conclusion Knees with incident TKA displayed smaller baseline cartilage thickness and greater lateral as well as location‐independent ordered value femorotibial cartilage loss than non‐TKAs. Discrimination of cartilage loss was greater for TKAs occurring within 2 years after the measurement than for those occurring later.
Type of Medium:
Online Resource
ISSN:
2151-464X
,
2151-4658
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2016713-1
detail.hit.zdb_id:
645059-3
