In:
Arthritis Care & Research, Wiley, Vol. 69, No. 1 ( 2017-01), p. 143-149
Abstract:
To assess the findings of contrast‐enhanced ultrasound (CEUS) of carotid arteries in patients with large vessel vasculitis (LVV) and to compare them with those observed using 18 F‐fluorodeoxyglucose–positron emission tomography ( 18 FDG‐PET). Methods A total of 31 consecutive patients with LVV (14 with Takayasu arteritis, 17 with giant cell arteritis with large vessel involvement) underwent both PET/computed tomography and carotid artery color Doppler ultrasound (CDUS) for a total of 35 combined assessments. Right carotid artery CEUS was performed after CDUS in all assessments. Kerr's criteria, a complete clinical examination, and acute phase reactants were simultaneously evaluated. The intensity of vascular uptake and vascularization of the carotid artery wall were compared. Results Ten 18 F‐FDG/PET scans showed active vascular 18 F‐FDG uptake (visual grade ≥2) in the right carotid artery. CEUS demonstrated severe vascularization (grade 2) within the right carotid artery wall in 12 examinations. The carotid CEUS vascularization grade significantly correlated with vascular 18 F‐FDG uptake ( P 〈 0.001) and maximum standardized uptake value (SUV) in the right carotid artery/mean SUV in the superior vena cava ( P = 0.001). When active vascular 18 F‐FDG uptake (≥2) was considered the gold standard for defining vascular inflammation, carotid CEUS had a sensitivity of 100% (95% confidence interval [95% CI] 65–100) and a specificity of 92% (95% CI 72–99). The positive likelihood ratio was 12.5 (95% CI 3.3–47.2). Severe vascularization at CEUS and active vascular 18 F‐FDG uptake were significantly more frequent in active disease according to Kerr's criteria compared to inactive ( P = 0.001 and P = 0.002, respectively). Conclusion Carotid CEUS vascularization grade and the grade of vascular inflammation on 18 F‐FDG‐PET were correlated in patients with LVV.
Type of Medium:
Online Resource
ISSN:
2151-464X
,
2151-4658
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2016713-1
