In:
Advanced Healthcare Materials, Wiley, Vol. 8, No. 22 ( 2019-11)
Abstract:
Repairing osteochondral defects is a considerable challenge because it involves the breakdown of articular cartilage and underlying bone. Traditional hydrogels with a homogenized single‐layer structure cannot fully restore the function of osteochondral cartilage tissue. In this study, a mussel‐inspired hydrogel with a bilayer structure is developed to repair osteochondral defects. The hydrogel is synthesized by simultaneously polymerizing two layers using a one‐pot method. The resulting upper and lower gelatin methacryloyl‐polydopamine hydrogel layers are used as cartilage and subchondral bone repair layers, respectively. Polydopamine‐induced hydroxyapatite in situ mineralization takes place in the lower layer to mimic the structure of subchondral bone. The bilayer hydrogel exhibits good mechanical properties for the synergistic effect of covalent and noncovalent bonds, as well as nanoreinforcement of mineralized hydroxyapatite. To improve the tissue‐inducibility of hydrogels, transforming growth factor β 3 is immobilized in the upper layer to induce cartilage regeneration, while bone morphogenetic protein 2 is immobilized in the lower layer to induce bone regeneration. Bone and cartilage repair performance of the hydrogel is examined by implantation into a full‐thickness cartilage defect of a rabbit knee joint. The bilayer‐structure hydrogel promotes regeneration of osteochondral tissue, thus providing a new option for repair of osteochondral defects.
Type of Medium:
Online Resource
ISSN:
2192-2640
,
2192-2659
DOI:
10.1002/adhm.201901103
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2645585-7
