In:
Advanced Healthcare Materials, Wiley, Vol. 12, No. 22 ( 2023-09)
Abstract:
As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen‐induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO 2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase‐like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)‐scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs’ therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.
Type of Medium:
Online Resource
ISSN:
2192-2640
,
2192-2659
DOI:
10.1002/adhm.202300163
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2645585-7
