In:
Advanced Materials, Wiley, Vol. 33, No. 7 ( 2021-02)
Kurzfassung:
Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by converting intracellular hydrogen peroxide (H 2 O 2 ) into highly toxic hydroxyl radicals ( • OH). To overcome the current limitations of the insufficient endogenous H 2 O 2 and the high concentration of glutathione (GSH) in tumor cells, an intelligent nanocatalytic theranostics (denoted as PGC‐DOX) that possesses both H 2 O 2 self‐supply and GSH‐elimination properties for efficient cancer therapy is presented. This nanoplatform is constructed by a facile one‐step biomineralization method using poly(ethylene glycol)‐modified glucose oxidase (GOx) as a template to form biodegradable copper‐doped calcium phosphate nanoparticles, followed by the loading of doxorubicin (DOX). As an enzyme catalyst, GOx can effectively catalyze intracellular glucose to generate H 2 O 2 , which not only starves the tumor cells, but also supplies H 2 O 2 for subsequent Fenton‐like reaction. Meanwhile, the redox reaction between the released Cu 2+ ions and intracellular GSH will induce GSH depletion and reduce Cu 2+ to Fenton agent Cu + ions, and then trigger the H 2 O 2 to generate • OH by a Cu + ‐mediated Fenton‐like reaction, resulting in enhanced CDT efficacy. The integration of GOx‐mediated starvation therapy, H 2 O 2 self‐supply and GSH‐elimination enhanced CDT, and DOX‐induced chemotherapy, endow the PGC‐DOX with effective tumor growth inhibition with minimal side effects in vivo.
Materialart:
Online-Ressource
ISSN:
0935-9648
,
1521-4095
DOI:
10.1002/adma.202006892
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2021
ZDB Id:
1474949-X
