In:
Advanced Synthesis & Catalysis, Wiley, Vol. 360, No. 15 ( 2018-08-06), p. 2925-2937
Kurzfassung:
A catalytic cascade has been developed for the synthesis of biaryl‐2‐methyl acetates via a palladium‐catalyzed ortho ‐C( sp 2 )−H bond arylation of pyruvate O ‐arylmethyl ketoximes with aryl iodides followed by a solvolysis, in which the pyruvic ketoxime ester as a new auxiliary is employed to direct the C( sp 2 )−H bond activation. The straightforward treatment of O ‐arylmethyl hydroxylamines and ethyl pyruvate with aryl iodides also provides the target products in a one‐pot fashion. Furthermore, the new palladacycle intermediate is unambiguously confirmed by single‐crystal X‐ray diffraction analysis. A plausible reaction pathway is proposed for the Pd‐catalyzed arylation‐acetolysis sequence. magnified image
Materialart:
Online-Ressource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v360.15
DOI:
10.1002/adsc.201800216
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2041384-1
ZDB Id:
2033084-4
