In:
Advanced Synthesis & Catalysis, Wiley, Vol. 360, No. 11 ( 2018-06-05), p. 2233-2238
Abstract:
An efficient route to synthesize chiral carbocyclic pyrimidine nucleoside analogues containing all‐carbon quaternary stereocenters has been established via the asymmetric intermolecular cyclopropanation of N1‐vinylpyrimidines and α‐aryl diazoesters. With 2 mol% of chiral dirhodium (II) carboxylate complex as the catalyst, a variety of chiral carbocyclic cytosine or uracil nucleoside analogues were obtained in good yields (up to 96% yield), high diastereoselectivities ( 〉 20:1 dr), and excellent enantioselectivities (up to 99% ee ). magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v360.11
DOI:
10.1002/adsc.201800222
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4