In:
American Journal of Hematology, Wiley, Vol. 67, No. 4 ( 2001-08), p. 270-272
Abstract:
Ubiquitin‐ and proteasome‐mediated protein degradation is involved in many intracellular processes, including cell cycle regulation, transcriptional activation, and signal transduction in all eukaryotes. Novel subfamily members of the ubp superfamily, DUB‐1 and DUB‐2, are known to be immediate–early genes and are specifically expressed in B‐lymphocytes and T‐lymphocytes, respectively. With the site‐directed mutagenesis in four conserved amino acids (Cys60, Asp133, His298, and His307) and a series of deletion in the carboxy‐terminal region, we demonstrate that these conserved amino acids are critical, but not the C‐terminus, for the deubiquitinating activity of DUB‐2. Am. J. Hematol. 67:270–272, 2001. © 2001 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0361-8609
,
1096-8652
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
1492749-4