In:
American Journal of Industrial Medicine, Wiley, Vol. 57, No. 7 ( 2014-07), p. 748-756
Abstract:
To assess the association between exposure, oxidative stress, symptoms, and cardiorespiratory function in wildland firefighters. Methods We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8‐iso‐prostaglandin F2α (8‐isoprostane) and 8‐hydroxy‐2'‐deoxyguanosine (8‐OHdG), and the smoke exposure marker (urinary levoglucosan). Arterial stiffness was assessed by examining levels of the aortic augmentation index, expressed as a percentage. An oxidative stress score comprising the average of z‐scores created for 8‐OHdG and 8‐isoprostane was calculated. Results Mean augmentation index % was higher for participants with higher oxidative stress scores after adjusting for smoking status. Specifically for every one unit increase in oxidative stress score the augmentation index % increased 10.5% (95% CI: 2.5, 18.5%). Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity. Conclusions Biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters. Am. J. Ind. Med. 57:748–756, 2014. © 2014 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0271-3586
,
1097-0274
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1491156-5
