In:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 141B, No. 5 ( 2006-07-05), p. 463-467
Kurzfassung:
Meniere's disease (MD) is characterized by spontaneous attacks of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. The majority of patients with MD appear sporadic but 5%–13% of the cases have a family history for the disease. The cause of both the sporadic and inherited forms of MD remains unclear despite a number of candidate genes defined from their association with hearing loss. We have performed a genome wide linkage scan on a large Swedish family segregating MD in five generations. Five candidate regions with a lod score of 〉 1 were identified. Two additional families with autosomal dominant MD were analyzed for linkage to these regions and a cumulative Z max of 3.46 was obtained for a single region on chromosome 12p. In two of the three families, a shared haplotype was found to extend over 1.7 Mb which suggests a common ancestral origin. Within this region, a single recombination event restricts the candidate region to 463 kb. © 2006 Wiley‐Liss, Inc.
Materialart:
Online-Ressource
ISSN:
1552-4841
,
1552-485X
DOI:
10.1002/ajmg.b.v141b:5
DOI:
10.1002/ajmg.b.30347
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2006
ZDB Id:
2143866-3
SSG:
12
