In:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 147B, No. 4 ( 2008-06-05), p. 531-534
Abstract:
Altered dopamine D2 receptor (D2R) is hypothesized to be a susceptibility factor for major psychosis. Recent studies showed that a new intracellular protein, prostate apoptosis response 4 (Par‐4), plays a critical role in D2R signaling. We conducted a genetic association analysis between Par‐4 gene (PAWR) and schizophrenia and mood disorders in a Japanese population (schizophrenia: 556 cases, bipolar disorder (BP): 150 cases, major depressive disorder (MDD): 312 cases and 466 controls). Applying the recommended ‘gene‐based’ association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant association was obtained found with schizophrenia or MDD or BP. We found a significant association of one tagging SNP with BP in a genotype‐wise analysis ( P = 0.0396); however, this might be resulted from type I error due to multiple testing ( P = 0.158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population. © 2007 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
1552-4841
,
1552-485X
DOI:
10.1002/ajmg.b.v147b:4
DOI:
10.1002/ajmg.b.30634
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2143866-3
SSG:
12