In:
Asian Journal of Organic Chemistry, Wiley, Vol. 10, No. 4 ( 2021-04), p. 831-837
Abstract:
A method for the radical cyclization of β,γ‐unsaturated oximes to access the isoxazoline backbone has been developed, in which iron(III) nitrate plays a dual role as a promoter and a nitrooxy source. Iron‐promoted cyclization is well tolerated with a series of aryl‐ and alkyl‐substituted β,γ‐unsaturated oximes, which readily affords the desired isoxazolines that can be easily transformed into useful compounds. Mechanistic experiments support that a radical pathway may be involved in the cyclization of β,γ‐unsaturated oximes.
Type of Medium:
Online Resource
ISSN:
2193-5807
,
2193-5815
DOI:
10.1002/ajoc.202100040
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2679333-7