In:
Annals of Neurology, Wiley, Vol. 82, No. 6 ( 2017-12), p. 1022-1028
Abstract:
Focal seizures are assumed to arise from a hypersynchronous activity affecting a circumscribed brain region. Using microelectrodes in seizure‐generating deep mesial regions of 9 patients, we investigated the firing of hundreds of single neurons before, during, and after ictal electroencephalogram (EEG) discharges. Neuronal spiking activity at seizure initiation was highly heterogeneous and not hypersynchronous. Furthermore, groups of neurons showed significant changes in activity minutes before the seizure with no concomitant changes in the corresponding macroscopic EEG recordings. Altogether, our findings suggest that only limited subsets of neurons in epileptic depth regions initiate the seizure‐onset and that ictogenic mechanisms operate in submillimeter‐scale microdomains. Ann Neurol 2017 Ann Neurol 2017;82:1022–1028
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2037912-2
