In:
Annals of Neurology, Wiley, Vol. 84, No. 1 ( 2018-07), p. 117-129
Abstract:
The goal of this study was to refine our understanding of disease risk attributable to common genetic variation in SNCA , a major locus in Parkinson disease, with potential implications for clinical trials targeting α ‐synuclein. We aimed to dissect the multiple independent association signals, stratify individuals by SNCA ‐specific risk profiles, and explore expression quantitative trait loci. Methods We analyzed participant‐level data from 12,503 patients and 12,502 controls, optimizing a risk model and assessing SNCA ‐specific risk scores and haplotypes as predictors of individual risk. We also explored hypotheses about functional mechanisms and correlated risk variants to gene expression in human brain and protein levels in cerebrospinal fluid. Results We report and replicate a novel, third independent association signal at genome‐wide significance level downstream of SNCA (rs2870004, p = 3.0*10 −8 , odds ratio [OR] = 0.88, 95% confidence interval [CI] = 0.84–0.92). SNCA risk score stratification showed a 2‐fold difference in disease susceptibility between top and bottom quintiles (OR = 1.99, 95% CI = 1.78–2.23). Contrary to previous reports, we provide evidence supporting top variant rs356182 as functional in itself and associated with a specific SNCA 5′ untranslated region transcript isoform in frontal cortex. Interpretation The SNCA locus harbors a minimum of 3 independent association signals for Parkinson disease. We demonstrate a fine‐grained stratification of α ‐synuclein–related genetic burden in individual patients of potential future clinical relevance. Further efforts to pinpoint the functional mechanisms are warranted, including studies of the likely causal top variant rs356182 and its role in regulating levels of specific SNCA mRNA transcript variants. Ann Neurol 2018;83:117–129
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2037912-2
