In:
Annals of Neurology, Wiley, Vol. 85, No. 5 ( 2019-05), p. 782-787
Abstract:
Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP Sc ) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt–Jakob disease (CJD), we applied 3 different anti‐PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV‐2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrP Sc immunodeposits with distinct morphology. Thus, PrP Sc in CJD affects the vagus nerve analogously to α‐synuclein in Parkinson disease. The morphologically diverse deposition of PrP Sc in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP Sc . Ann Neurol 2019;85:782–787
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2037912-2