In:
Annals of Neurology, Wiley, Vol. 29, No. 1 ( 1991-01), p. 95-97
Abstract:
We studied the susceptibility to prion infection of the trisomy 16↔diploid chimeric mouse, a putative model of Down syndrome. When weanling chimeras were inoculated intracerebrally with scrapie prions, the time until appearance of the first symptoms of scrapie was reduced by 17 days (from a mean control time of 153 days) and the time to death was reduced by 30 days (from control time of 170 days). Our results with trisomy 16 chimeras argue that the susceptibility to central nervous system degeneration caused by prions can be modulated by chromosome imbalance.
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
DOI:
10.1002/ana.410290117
Language:
English
Publisher:
Wiley
Publication Date:
1991
detail.hit.zdb_id:
2037912-2