In:
Angewandte Chemie, Wiley, Vol. 127, No. 45 ( 2015-11-02), p. 13451-13455
Kurzfassung:
A new method for the construction of five‐membered spirocyclic oxindoles is based on a Michael–Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine‐derived squaramide. The desired products were obtained in excellent yields (up to 94 %) and stereoselectivities (up to 〉 20:1 d.r., 〉 99 % ee ). A scaled‐up variant also proceeded smoothly showing that the one‐pot reaction might find application in the synthesis of bioactive‐compound libraries.
Materialart:
Online-Ressource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v127.45
DOI:
10.1002/ange.201506206
Sprache:
Deutsch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
505868-5
ZDB Id:
506609-8
ZDB Id:
514305-6
ZDB Id:
505872-7
ZDB Id:
1479266-7
ZDB Id:
505867-3
ZDB Id:
506259-7