In:
Angewandte Chemie, Wiley, Vol. 132, No. 49 ( 2020-12), p. 22143-22148
Abstract:
A ruthenium‐catalyzed formal anti‐Markovnikov hydroamination of allylic alcohols for the synthesis of chiral γ‐amino alcohols is presented. Proceeding via an asymmetric hydrogen‐borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral γ‐amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to 〉 99 % ee ).
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v132.49
DOI:
10.1002/ange.202009754
Language:
English
Publisher:
Wiley
Publication Date:
2020
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