In:
Angewandte Chemie, Wiley, Vol. 133, No. 15 ( 2021-04-06), p. 8531-8535
Abstract:
Understanding the complex interplay among gasotransmitters is of great significance but remains technically challenging. In this study, we present the design and synthesis of a dually responsive BOD‐NH‐SC reporter for probing the dynamic and alternating existence of NO and H 2 S in living cells. This designed reporter can repeatedly cycle S‐nitrosation and transnitrosation reactions when successively treated with NO and H 2 S, thus affording the interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H 2 S). In light of this unique fluorescence alternation between two colors, we synthesized water‐soluble BOD‐NH‐SC dots to visualize the intracellular dynamics of NO and H 2 S. These molecular probes thus provide a toolbox to elucidate the interplaying roles of NO and H 2 S in the complex interaction networks of various signal transduction pathways.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.15
DOI:
10.1002/ange.202015650
Language:
English
Publisher:
Wiley
Publication Date:
2021
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