In:
Angewandte Chemie, Wiley, Vol. 134, No. 22 ( 2022-05-23)
Abstract:
We describe the development of an efficient method for the olefination of hydrazones and oximes. The key design approach that enables this transformation is tuning of the energy/polarity of C=N π‐bonds by employing heteroatom functionalities (NR 2 , OR). The resulting hydrazones or oximes facilitate olefination with ruthenium alkylidenes. Through this approach, we show that air‐stable, commercially available ruthenium alkylidenes provide access to functionalized alkenes (20 examples) in ring‐closing reactions with yields up to 88 %.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v134.22
DOI:
10.1002/ange.202112101
Language:
English
Publisher:
Wiley
Publication Date:
2022
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