In:
Angewandte Chemie, Wiley
Abstract:
New generation of nanomaterials with organelle‐level precision provide significant promise for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we report a novel amphiphilic phenolic polymer (PF) for the mitochondria‐targeted photodynamic therapy (PDT), which can trigger excessive mitochondrial DNA (mtDNA) damages by the synergistic action of oxidative stress and furan‐mediated DNA cross‐linking. Moreover, the phenolic units on PF enable further self‐assembly with Mn2+ via metal‐phenolic coordination to form metal‐phenolic nanomaterial (PFM). We focus on the synergistic activation of the cGAS‐STING pathway by Mn2+ and tumor‐derived mtDNA in tumor‐associated macrophages (TAMs), and subsequently repolarizing M2‐like TAMs to M1 phenotype. We highlight that PFM facilitates the cGAS‐STING‐dependent immunity at the organelle level for potent antitumor efficacy.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.202411498
Language:
English
Publisher:
Wiley
Publication Date:
2024
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