In:
Angewandte Chemie International Edition in English, Wiley, Vol. 34, No. 2 ( 1995-02-03), p. 141-154
Abstract:
The designation “scourge of mankind” has been attached to parasitic infections such as Chagas' heart disease, sleeping sickness, and malaria. In many countries of the world they lead to human misery and massive socio‐medical problems. Several approaches are possible for the design of chemotherapeutic agents that can interfere as enzyme inhibitors with the metabolism of parasites. For instance, structural motifs of an enzyme and its natural substrates can be expolited to control the kinetics of the enzyme–substrate interactions, and thus substrate analogues can influence the enzyme as inhibitors at various stages of the catalytic cycle. The results may be irreversible inhibition, destabilization of the enzyme's structure, or an alteration of its substrate specificity. Glutathione reductase and trypanothione reductase are target enzymes for this strategy of drug design in the fight against tropical diseases.
Type of Medium:
Online Resource
ISSN:
0570-0833
DOI:
10.1002/anie.199501411
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7