In:
Angewandte Chemie International Edition, Wiley, Vol. 56, No. 15 ( 2017-04-03), p. 4135-4139
Kurzfassung:
The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf) 2 and a chiral cationic ruthenium–diamine complex. A range of chiral 1 H ‐isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1 H ‐isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.
Materialart:
Online-Ressource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201611291
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
2011836-3
ZDB Id:
123227-7