In:
Angewandte Chemie International Edition, Wiley, Vol. 56, No. 46 ( 2017-11-13), p. 14360-14382
Abstract:
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to “nutritional immunity”. However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201701586
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
