In:
Applied Organometallic Chemistry, Wiley, Vol. 34, No. 11 ( 2020-11)
Abstract:
Using the mixed‐ligand method, a novel coordination polymer containing Co(II) of [Co(ditb)(tdc)] n ·5 n H 2 O ( 1 ) was prepared by reacting rigid 2,5‐thiophenedicarboxylic acid with flexible 1,4‐di(1H‐1,2,4‐triazol‐1‐yl)butane using the slow evaporation method. Active samples of 1 ( 1a for short) showed good stability and the ability to capture CO 2 . It can be used as a potential heterogeneous catalyst for chemical immobilization of epoxide and CO 2 to form cyclic carbonates. In addition, catalyst 1a retained its original structure after four times of reuse. Its biological properties were assessed against Mycobacterium tuberculosis ( M.TB ) both in vivo and in vitro. First, the bactericidal ability of the compound against M.TB was measured by a sterilization curve. Then, the expression of pckA gene related to M.TB survival was detected using reverse transcription‐polymerase chain reaction. For the in vivo study, the colony‐forming unit determination was performed for evaluating the anti‐bacterial effect of the compound, and the enzyme‐linked immunosorbent assay was used for the inflammatory cytokine measurement in vivo. Through molecular docking simulations, all three types of polar atoms on the complex were confirmed to have chances of interacting with the protein.
Type of Medium:
Online Resource
ISSN:
0268-2605
,
1099-0739
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1480791-9