In:
Archiv der Pharmazie, Wiley, Vol. 315, No. 10 ( 1982-01), p. 872-877
Kurzfassung:
Synthesis and Bioactivities of Some Derivatives of Naphtho[1,2‐ d ]thiazolo[3,2‐ a ]pyrimidin‐4‐one In continuing the study of the structure‐activity relationships of compounds of the naphtho[1,2‐ d ]thi azolo[3,2‐ a ]pyrimidine series, the 4‐oxo derivatives 5a–d were synthesized in addition to the 2‐oxo compounds reported previously. The synthesis was accomplished by nucleophilic attack of 2‐aminonaphtho[1,2‐ d ]thiazole (2) on the corresponding β‐keto esters 3a–d . Unlike the 2‐oxo derivatives, the products showed no hypotensive effect on normotensive rats. However, all compounds exhibited a pronounced diuretic activity in the same animals after oral administration of 10–30 mg/kg. The activity persisted in most cases for more than five hours.
Materialart:
Online-Ressource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.v315:10
DOI:
10.1002/ardp.19823151010
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1982
ZDB Id:
1496815-0
SSG:
15,3