In:
Archiv der Pharmazie, Wiley, Vol. 327, No. 4 ( 1994-01), p. 225-231
Abstract:
Synthesis of 5 H ‐Pyrido[2,3‐ c ]‐2‐benzazepines The title compounds can be obtained by two differend ways: Ring closure of 2‐benzazepine enaminonitrile 1 and the C 2 ‐building blocks 2, 7 and 8 gives rise to the title compounds 6, 9 and 10 . ‐ The second way starts with Wolff‐Kishner ‐reduction of the 2‐amino‐3‐benzoylpyridines 16a,b to the 2‐amino‐3‐benzylpyridines 18a,b . Benzoylation of 18a,b leads to the dibenzoylated compounds 20 and 21 , respectively, which can be transformed to the monobenzoylated pyridines 22 resp. 23 . Applying the Bischler‐Napieralski ‐reaction on 22a,b and 23a,b leads to the 5 H ‐pyrido[2,3‐ c ]‐2‐benzazepines 24a,b and 25a,b . By means of 1 H‐, 13 C‐ and 15 N‐NMR‐data it is demonstrated that ethyl benzoylcyanacetimidate ( 12a ) exists as benzoylketene‐ O,N ‐acetal 12a AE .
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.19943270407
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1496815-0
SSG:
15,3
