In:
Archiv der Pharmazie, Wiley, Vol. 348, No. 11 ( 2015-11), p. 776-785
Abstract:
A series of novel 7‐methoxy‐3‐heterocyclic quinolin‐6‐ol derivatives were synthesized and evaluated for their anti‐hepatitis B virus (HBV) activities and cytotoxicities in the HepG2.2.15 cell line. Five compounds, 14a , 15c , 15e , 16b , and 16f , displayed excellent potency and selectivity toward the HBV, with IC 50 values of less than 5.0 µM and selectivity index values of 11.0–71.5. Structure–activity relationship studies indicated that the 1,3,4‐thiadiazole and sulfinylmethyl derivatives showed the most potent activities against the HBV.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.v348.11
DOI:
10.1002/ardp.201500238
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1496815-0
SSG:
15,3