In:
Archiv der Pharmazie, Wiley, Vol. 351, No. 12 ( 2018-12)
Abstract:
New therapeutics are urgently needed to fight tuberculosis and mycobacteria‐related diseases that are a major health hazard especially in poor countries. Natural products have been the source of important antitubercular drugs in the past and still need to receive attention as a potent reservoir of chemical structures. Fifteen known and two new (+)‐usnic acid (a benzofurandione formerly isolated from lichens) enamines and hydrazones are here described and tested against sensitive and multidrug‐resistant strains of mycobacteria. Among several (+)‐usnic acid conjugates, PS14 and PS18 showed potent activity against both susceptible and resistant Mycobacterium tuberculosis strains (MIC values of 1–32 and 2–32 mg/L, respectively) comparable with MIC of other antitubercular drugs already in use for tuberculosis treatment.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.v351.12
DOI:
10.1002/ardp.201800177
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1496815-0
SSG:
15,3