In:
Arthritis & Rheumatology, Wiley, Vol. 69, No. 2 ( 2017-02), p. 309-319
Abstract:
To validate the measurement properties and the detection performance of the FLARE‐RA questionnaire in a longitudinal prospective study. Methods To validate the FLARE‐RA self‐administered questionnaire, we conducted a prospective trial in rheumatoid arthritis (RA) patients to document: 1) content and construct validity by factor analysis, convergent validity by Pearson's correlation with routine assessment of patient index data (Routine Assessment of Patient Index Data 3 [RAPID‐3] questionnaire), RA Impact of Disease (RAID) score, Disease Activity Score in 28 joints (DAS28), and Health Assessment Questionnaire (HAQ), 2) reliability (intraclass correlation coefficient [ICC] and Bland‐Altman plot), and 3) feasibility of use. Patients were examined and questionnaires were collected at baseline and 3 months, and every week in between for RAPID‐3. Results We recruited 138 patients from 13 centers: 81.9% women, mean age 57.4 years, mean DAS28 2.9, mean C‐reactive protein level 6.2 mg/liter, 84.4% rheumatoid factor positive, 78.0% anti–citrullinated protein antibody positive, and 78.8% with erosive disease. At baseline, the mean ± SD FLARE‐RA score was 2.3 ± 2.3. The content and construct validity of FLARE‐RA was good. A substantial floor effect, but no ceiling effect, was observed. Principal components analysis revealed 1 domain disentangled in 2 subdomains: physical and emotional. The FLARE‐RA total score was correlated with the DAS28 (r = 0.63, P 〈 0.001), RAID (r = 0.80, P 〈 0.001), RAPID‐3 (r = 0.77, P 〈 0.001), and HAQ (r = 0.53, P 〈 0.001). The ICC for reliability was 0.94 (95% confidence interval 0.92–0.96). Conclusion The FLARE‐RA self‐administered questionnaire represents a valid and valuable instrument to detect RA flare between visits to the physician.
Type of Medium:
Online Resource
ISSN:
2326-5191
,
2326-5205
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2754614-7