In:
Chemistry – An Asian Journal, Wiley, Vol. 11, No. 5 ( 2016-03-04), p. 691-695
Abstract:
A highly enantioselective ring‐opening alkylation reaction between 3‐aryl‐oxindole and N ‐(2‐ p icolinoyl) aziridine has been realized for the first time. The reaction is efficiently mediated by a simple in‐situ‐generated magnesium catalyst and 3,3′‐fluorinated‐BINOL (BINOL=1,1′‐binaphthalene‐2,2′‐diol) has been identified as a powerful chiral ligand. Notably, the fluorine atom on the chiral ligand plays a key role in providing the desired chiral 3‐alkyl‐3‐aryl oxindoles with excellent enantioselectivities.
Type of Medium:
Online Resource
ISSN:
1861-4728
,
1861-471X
DOI:
10.1002/asia.201501369
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2233006-9