In:
Chemistry – An Asian Journal, Wiley, Vol. 11, No. 9 ( 2016-05-06), p. 1406-1413
Kurzfassung:
Our first‐generation synthetic study towards the total synthesis of propindilactone G ( 1 ) and its analogues is reported. The key synthetic steps were an intramolecular Pauson–Khand reaction (PKR) and a vinylogous Mukaiyama reaction (VMAR). The stereoselective synthesis of the CDE ring moiety with an all‐carbon quaternary center through a PKR was difficult, whilst a VMAR afforded a product with the opposite stereochemistry at the C20 position on the side chain. These results led us to redesign our synthetic strategy for the total synthesis of compound 1 .
Materialart:
Online-Ressource
ISSN:
1861-4728
,
1861-471X
DOI:
10.1002/asia.201600129
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2233006-9
