In:
Biomedical Chromatography, Wiley, Vol. 36, No. 8 ( 2022-08)
Kurzfassung:
To minimize drug‐related toxicity and monitor dosing regimens, an ultra‐sensitive, simple and high‐throughput analytical method for therapeutic drug monitoring is required. A novel LC–MS/MS bioassay of levetiracetam, lamotrigine and 10‐hydroxycarbazepine in human plasma was established. The analytes were separated on a Hypersil GOLD™ C 18 column under a 2.5 min isocratic elution after one‐step protein precipitation. MS detection was performed under electrospray ionization positive‐mode fitted with selected reaction monitoring. The validated ranges were 0.1–20 μg/ml for LTG, 0.3–60 μg/ml for 10‐hydroxycarbazepine and levetiracetam. The intra‐ and inter‐batches of precision and accuracy was within ±15%. The novel method met all other criteria. Conclusion: This method can be used to monitor drug concentrations and decision‐making in epileptic patients.
Materialart:
Online-Ressource
ISSN:
0269-3879
,
1099-0801
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2022
ZDB Id:
1479945-5
SSG:
12