In:
Brain and Behavior, Wiley, Vol. 5, No. 9 ( 2015-09)
Kurzfassung:
Stress coping has been defined as the cognitive and behavioral efforts made to conquer, endure, or decrease external and internal demands and the conflicts between them. It has two main elements: the control or modification of the person–environment relationship causing the stress (i.e., problem‐focused coping) and/or regulation of stressful feelings (i.e., emotion‐focused coping). Research suggests that the expressions of brain‐derived neurotrophic factor ( BDNF ) and neurotrophic tyrosine kinase receptor type 2 ( NTRK 2) play important roles in brain adaptation to investigate stress. To clarify the genetic basis of stress coping, we investigated the association of stress‐coping strategies and social adaptation with single‐nucleotide polymorphisms ( SNP s) involved in neural plasticity, anxiety, and depression. Methods In 252 healthy controls (94 women; 158 men), we measured and estimated the stress‐coping style using the Lazarus‐type stress‐coping inventory, ego aptitude scale ( EAS ), and social adaptation self‐evaluation scale ( SASS ). We investigated one SNP of BDNF (rs6265, Val/Met) and five SNP s of NTRK 2 (rs11140800, rs1187286, rs1867283, rs1147198, and rs10868235). Results We observed significant associations between BDNF and emotion‐focused strategies, seeking social support, self‐control, and distancing. We also found significant associations between NTRK 2 and cognitive strategies, problem‐solving, confrontive‐ coping, seeking social support, distancing and positive reappraisal. Significant associations were also found between BDNF and critical attitudes and between NTRK 2 and all seven ego‐related factors on the EAS . In the SASS , the minor allele rs1867283 of NTRK 2 had a significantly higher score than the heterozygote. Conclusions These findings may provide insights into the partial effects of genetic mutations in BDNF and NTRK 2 on stress tolerance and personality.
Materialart:
Online-Ressource
ISSN:
2162-3279
,
2162-3279
DOI:
10.1002/brb3.2015.5.issue-9
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2623587-0
